The comparative study of intravenous Ondansetron and Dexamethasone Effects on Reducing the Incidence of PostSpinal Anesthesia Hypotension in Elderly Patients Undergoing Urologic Surgeries

The aim of this study is to investigate the effect of preventive administration of two drugs (ondansetron and dexamethasone) on reducing hypotension and bradycardia in elderly patients undergoing spinal anesthesia.

double blind randomized controlled trial on 120 patients who were Candidate for elective urology surgeries

120 patients ,attending Shahid Beheshti and Modarres Hospitals are divided into three groups . Group A: 4 mg Ondansetron, 5 minutes before S.A is injected . Group B: 5 minutes before spinal anesthesia, 8 mg of intravenous Dexamethasone is injected Group C: Medicine is not injected before S.A.. Blood pressure and heart rate monitoring is recorded in all 3 groups before & 30 minutes following the S.A

Inclusion ≤65 of age American Society of Anesthesiologists (ASA) physical status I, II EF>40% Patients who do not have a contraindication for spinal anesthesia (such as coagulation disorder, thrombocytopenia). Not allergic to local anesthetic No allergy to ondansetron or dexamethasone Not taking drugs related to steroids or serotonin (for example, selective serotonin reuptake inhibitors) Not suffering from uncontrolled cardiovascular, kidney, liver and thyroid diseases Exclusion Study confounding items such as: Occurrence of surgical complications such as bleeding, hemodynamic instability

The patients are selected and randomly divided into 3 groups of 40 patients: First intervention group، Group A: 5 minutes before spinal anesthesia, 4 mg Ondansetron is injected intravenously Second intervention group Group B: 5 minutes before S A, 8 mg Dexamphetamine is injected & the control group Group C: No medicine is injected before S.A.

Systolic and Diastolic blood pressure, Heart rate, Ondansetron, Dexamethasone, Atropine, Ephedrine

120 patients. are randomly assigned based on the inclusion and exclusion crietria, using the software of the website http://www.Randomization.com . Their information are registered and informed consent obtained. Based on the central randomization system , the patient is assigned to the study groups by contacting the randomization center . This is done by a hospital colleague not involved in other stages of the study .

.Patients are classified into three groups according to the randomization program and entered into the study according to the determined codes. In order to complete the study, the anesthesiologist assistant who is not participating in the study gives i.v. injections of Ondansetron or Dexamethasone in a 5 cc syringe preparation, 5 minutes prior to the spinal anesthesia. The patient, the caregivers of the operating room, the evaluator and the data analyst. are unaware of the type , dosage of drug injected.

Data recording sheets، Result Charts , Analytical Charts available in article link and research text

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