Investigating the effect of using ibuprofen and netonal drugs before root canal treatment on the pain after treatment in teeth with irreversible pulpitis

ِDetermining the effect of using ibuprofen and netonal drugs before root canal treatment on the pain after treatment in teeth with irreversible pulpitis

A clinical trial type study with a control group, with parallel groups, double-blind, randomized, phase 3 on 60 patients, for randomization, each person was assigned a number using the Random Allocation software and the patients based on that Number were placed in one of the three treatment groups of ibuprofen, netonal or placebo.

. Place: Department of Endodontic Treatment, Faculty of Dentistry, Isfahan University of Medical Sciences, Iran. Patients completed the pain scales. For intervention group 1, ibuprofen, intervention group 2, netonal and control group, placebo were prescribed. Anesthesia was administered and 10 minutes later, pain score was recorded. Filing channels were done. Pain was recorded immediately and 8, 12 and 24 hours after the treatment. The intervention was blinded to the patients and researchers.

Inclusion: patients with irreversible pulpitis of mandibular first or second molar teeth, spontaneous tooth pain based on VAS or Wong-Baker shape scale at least 30 mm, normal dental radiography, no lesion or sinus tract, long response to electrical test Pulp and cold test with a cotton roll cooled by endo- ice Exclusion: use of analgesics in the last 12 hours, long-term use of drugs that interfere with non-steroidal anti-inflammatory drugs, sensitivity to non-steroidal anti-inflammatory drugs or lidocaine, chronic systemic disease, pregnant mothers, teeth with periapical lesions. and chronic periapical abscess, patients with periodontal invasion, patients with irreparable teeth or with previous restorations.

Intervention1: Ibuprofen Intervention 2: Netonal Placebo: Control

pain

The patients were selected by convenience sampling method. Block randomization method was used for random assignment to groups. Random Allocation Software was used for block randomization. On the first page of this software, the number of groups and sample size were entered. On the next page of the software, it was determined how many blocks should be. Blocks with a length of six cells were selected. In the next step, the software created a list of numbers along with grouping. A number was assigned to each patient in the order of entry, and based on that number, the patients were assigned to one of the three treatment groups: ibuprofen, netonal, or placebo in one of the blocks. This action continued until 20 people were entered in each group and 60 people were selected.

All drugs were similar in shape, color and size. In order to simulate the drugs, the tablets were divided into small pieces and then they were put into capsules of the same color and the same size. The placebo substance (sugar) was placed inside the same type of capsules without any need to change.