Efficacy, safety, satisfaction, toleberility and treatment duribility of long-pulsed Nd:YAG 1064 nm laser compared with fractional Q-switch Nd:YAG 1064 nm laser in the treatment of active acne vulgaris in patients under treatment with azithromycine: An assessor-analyst-blinded split-body triple-arms randomized controlled clinical trial

Determining of effectiveness of fractional Q switch laser compared with Nd:YAG laser in the treatment of active acne of face

Clinical trial with control group, Single-blind , randomized on 20 patients, simple randomization was used for randomization

In all patients who entered the study with active acne, before the start of the study, using Canon EOS 750D digital photography camera with the same distance and high quality, the desired images of the patients will be prepared. Each patient is treated with laser for three sessions with an interval of 3 weeks, and evaluation is done at each visit and 4 weeks after the last laser session. Evaluation of the study results by an evaluator blinded to the type of intervention and based on the images prepared by Waste will be done in each meeting.

The criteria for entering the study are according to the following: 1. Patients 15 to 50 years old 2. Patients with a confirmed diagnosis of active facial acne 3. The patient has not received any treatment for his illness in the past three months. 4. Lack of serious underlying disease 5. The patient's cooperation in carrying out therapeutic interventions and referring for all therapeutic sessions

The study population is patients with moderate to severe active facial acne referring to Hazrat Rasool Akram Hospital. Affected patients were examined by a dermatologist, and if there were entry criteria and no exit criteria, they were entered into the plan by the available method, and for each patient, fractional Kioswitch laser was performed on one side of the face and Nd:YAG laser on the opposite side. will be Also, forehead or trunk acne of the patient is considered as a control group.

Effectiveness of treatment; Safety of treatment; Tolerability of treatment; Satisfaction with treatment

For each patient in a random way and using sealed envelopes A and B, on one side of the face,will treated with fractional Q-switch laser and on the opposite side, Nd:YAG laser. The right side of the face of group A will treaated with Q-switch laser and the left side will treated with Nd:YAG laser and vice versa. Also, the patient's forehead or trunk acne is considered as a control group.

The evaluation of the results of the studies will be done by a dermatologist as a blind evaluator to the type of intervention and based on the clinical images of the patients' faces in each session. Due to the clear difference between the mentioned therapeutic interventions, it was not possible to blind the therapist and as a result, the study will be conducted in a one-sided blind manner.