Determining and comparing the effect of Clotrimazole vaginal cream and Prongus Fluorase vaginal cream (Jashir plant) on candidal vulvovaginitis

Determining the effect of Prongus Fluorase vaginal cream on candidal vulvovaginitis Comparison of Clotrimazole vaginal cream and Prongus Fluorase vaginal cream on candidal vulvovaginitis

A clinical trial with a control group with a parallel group, three-blind, randomized on 112 patients, the rand function of Excel

, The vulvovaginal symptoms form in Women's clinic is completed, the mental symptoms of the vulvar and vagina such as itching, burning, and dyspareunia are determined by the client on a 10 cm visual analog scale, and the objective symptoms are recorded in the checklist according to the examiner's observations and the scoring system. Sobel placement is graded. Determining the severity and classification of candidal vulvaginitis is done through the total score of objective and subjective symptoms in the Sobel clinical scoring system. Total Sobel score greater than 4 is considered as a possible diagnosis of candidal vulvovaginitis, then using three swabs, one of the swabs is drawn on the slide and a drop of normal xylene is added and the prepared wet slide is examined, and the second swab is examined for fungal elements, potassium hydroxide is added.The researcher, the statistical analyst and the patient are blinded

Entry conditions: women of reproductive age, being married, having at least two symptoms of cheesy secretions and itching and a minimum Sobel score of 4 or a positive culture. No entry: lactating women, postmenopausal women, pregnant women, suffering from diabetes, history of allergy to jashir, history of allergy to clotrimazole vaginal cream.

Intervention group: Jashir vaginal cream Control group: clotrimazole vaginal cream for one week, one 5 mg applicator

Direct observation of the vagina, vaginal pH, wet vaginal smear, culture of vaginal secretions

For sampling, the available sample method is used, then the research units are placed in two parallel groups by a simple random allocation method using a table of random numbers. 56 women are in clotrimazole vaginal cream users group and 56 women are in Jashir vaginal cream group.

All people, including the researcher, the patient and the statistical analyst, are blinded to the drug allocation. The pharmacist will perform drug blinding. In order to blind Clotrimazole 1% cream made by a pharmaceutical company, under sterile conditions, it is emptied by the pharmacist into tubes similar to Jashir's vaginal cream tubes, then in order to differentiate the two drugs, they are coded as A and B codes by the pharmacist for each Vaginal cream is determined and after the study and statistical analysis, the code of each drug is stated by the pharmacist. The research team includes a gynecologist, a pharmacist and a midwife

Individual data of participants by de-identifying individuals, research results

Access period from 1402 to one year

All researchers in academic and scientific institutions

Study method and statistical analysis

To the email address sf.hekmatzadeh@yahoo.com Yasuj University of Medical Sciences, Fatemeh Hekmatzadeh

Request by email or attendance at Yasouj University of Medical Sciences