Investigating the effect of tranexamic acid in preventing dry socket syndrome following surgical extraction of the impacted third molar of the mandible

The effectiveness of the use of tranexamic acid in preventing the occurrence of dry cavity after mandibular third molar surgery.

A parallel group clinical trial with case and control in one person in a split mouth, single blind, randomized, phase 3 on 72 patients. The randomization tool is a sealed envelope with a random sequence

study is a clinical research (randomized controlled trial). Research data are collected from clinical trial findings in patients referred to maxillofacial surgery department of Azad Islamic Faculty of Dentistry in Tehran in academic year 1401-1402. Tranexamic acid drug used is 250 mg capsule powder. On the side of the intervention, wash area and the cavity are filled with tranexamic acid capsule powder and sutured. then a sterile gauze is placed in the area for 30 min. On the control side, a sterile gauze is placed in place without using any local coagulant. Unilateral blinding and The person is the evaluator.

Inclusion criteria: Age between 18 and 35 years, lower mandibular third molar teeth, partially embedded, bilaterally, exclusion criteria: no blood diseases such as anemia, thalassemia, and hemophilia, no contraindications for the administration of corticosteroids

All patients undergo wisdom tooth extraction surgery by one person. The tranexamic acid used is in the form of 250 mg capsule powder. On the intervention side, the area is washed and the cavity is filled with tranexamic acid capsule powder and sutured, and then a sterile gauze is placed in the area for 30 min . On the control side, a sterile gauze is placed in place without using any local coagulant

Occurrence of dry socket phenomenon

In this study, we used the restricted randomization method randomization (block randomization type) We will use randomization. . The size of all the blocks is equal and we are in this Single-group trial of 4 blocks (including 4 participants in We will have an intervention group and a control). The randomization tool is also from sequence generation software Random (random software allocation) is used that this Random sequence generation software is capable of simple randomization They are used to generate random sequences using the block method. To hide We use Concealment Allocation We use the method used to execute the sequence Randomization is applied to the participants in the study, in a way Before assigning the individual, the assigned group is not clear. With from sealed opaque envelopes with random sequence (envelopes opaque, sealed, numbered Sequentially (which in In this method, each random sequence is created on a card It is registered and the cards are placed in the envelopes in order become In order to preserve the random sequence on the outer surface of the envelope Numbering is done in the same order. Finally, the envelope door The letters are glued and placed in a box in order. At The time of starting the registration of participants, based on the order of entry of the company Eligible candidates to study, one of the letter envelopes in open order and the assigned group of that participant is revealed.

The evaluator does not know the type of intervention and the study is conducted in a single blind manner.