Inclusion criteria:
To diagnose polycystic ovary syndrome according to the Rotterdam criteria, two of the following must be present: 1- Amenorrhea or reduced ovulation frequency
Presence of hyperandrogenism based on clinical symptoms (hirsutism and male pattern hair loss) or laboratory (androgen increase) free or increased free androgen index)
the presence of evidence of polycystic ovary in ultrasound.
Exclusion criteria:
People who use tobacco and alcohol.
People suffering from chronic kidney, liver, lung diseases and chronic or acute inflammatory diseases (especially acute inflammation of the pancreas), thyroid dysfunction, heart valve disease, short bowel syndrome.
Also, people with low ability of immune system (autoimmunity) are removed from the list of eligible people. These conditions are approved by the clinical consultant in the case of the studied subjects.
Also, people who are allergic to medicine or placebo during the study.
or taking chemotherapy drugs (tamoxifen) and corticosteroids, or drugs affecting blood sugar and lipids (insulin injections, statins, diuretics), antibiotics and vitamin supplements and omega 3, or suffering from one of the above-mentioned diseases Either they were admitted to the hospital or they had to change the dosage of the drugs they were taking, they were excluded from the study.
To overcome the confounding factors, we use the general information questionnaire and the three-day record of people's food intake.