A comparative study of the effect of adding intravenous dexmedetomidine or intraperitoneal dexmedetomidine to intraperitoneal bupivacaine on pain after laparoscopic cholecystectomy.

Comparison of the effect of intraperitoneal dexmedetomidine or intravenous dexmedetomidine in combination with intraperitoneal bupivacaine on pain after laparoscopic cholecystectomy.

Randomised,with a control group, parallel group trial with blinded outcome assesment, randomisation was done with random allocation software.

This study is a triple-blineded randomized clinical trial on 90 patients who are candidates for laparoscopic cholecystectomy in Al-zahra operating room at isfahan city. After the approval of the ethics committee of the university and obtaining the consent of the patients, the patients will be randomly assigned into 3 groups,in each group the intended intervention is applied and the patient's data and symptoms are recorded. In case of any change in anesthesia method and change of operation to open type, patients will be excluded from the study. The patients, the researcher who records the patient's symptoms, and the analysts who analyze the collected data don't know the type of intervention applied in each group and therefore they are all blind.

•Inclusion criteria: candidate patiants for laparoscopic cholecystectomy surgery, age between 18-65 years old, ASA I & II. •Excluision criteria: patients with a history of allergy to the drugs used in the study, patients with inability to express the intensity of pain based on the VAS criteria.

Group 1: 20 ml bupivacaine 0.25% with dexmedetomidine at a dose of 1 μg/kg intraperitoneally, group 2: 20 ml bupivacaine 0.25% intraperitoneally and dexmedetomidine at a dose of 1 μg/kg iv.control group 22cc N/S intraperitoneal

vas pain score, dosage of additional analgesic, frequency of nausea & vomiting, palse rate, 02 saturation

Randomization will be done by the simple method , the samples are randomly placed in three intervention groups 1 and 2 and control by random allocation software. Sampling continues until the samples in all three groups reach the set limit.

This study is a triple blind clinical trial,in this way, the patient is included in the study but does not know the type of intervention applied and is blind, the person who records the patient's symptoms is also different from the person who injects the drug And without knowing the type of drug, only records the patient's symptoms during the study and therefore is kept blind. The analysts who analyze the data collected during the study also do not know the type of intervention applied in each group and are blind.