Comparison of the effect of adding Dexamethasone and Fentanyl to Bupivacaine in transverse abdominal plane block (TAP) on pain intensity after cesarean section by spinal anesthesia in Sari Emam hospital in 1401

Comparison of the effect of adding dexamethasone and fentanyl to bupivacaine in transverse abdominal plane (TAP) block on pain intensity after cesarean section using spinal anesthesia.

Clinical trial with a control group, with parallelgroups,3blindstrains,randomized, phase 2 on 60 patients. Now, randomization will be done by block method (Randomization Block). This process will be done with Random allocation software. Data entry and analysis will be done in SPSS version 25 software.

The current study is a three-blind randomized clinical trial that will be conducted at Imam Khomeini Educational-Therapeutic Hospital in Sari in Mazandaran province on women who are candidates for elective cesarean birth between 18 and 50 years old. These women are selected for the study based on American Society of Anesthesiology (ASA) physical status Ⅰ and Ⅱ.

Patients 18-50 years old, patients undergoing cesarean section under spinal anesthesia, patients with anesthesia class I and II of the American Society of Anesthesiology (ASA) (ASA definition I = healthy patient without organic disease, (VAS; scale 0-10), They were eligible to provide written informed consent to enroll in the study. Body mass index = 23.9-18.5 kg/m2, absence of coagulopathy, absence of alcohol or drug addiction, exclusion criteria, presence of chronic pain, or havingunderlyingdiseasestakingpainkillersbeforesurgery,presenceofinfectionhistoryof abdominal surgery or trauma, respiratory tract infection within 2 weeks

Group (1) 50 micrograms of fentanyl plus 17 ml of 0.25%bupivacaineand2mlof 0.9% normal saline in a total volume of 20 ml on each side Group (2) 4 mg of dexamethasone plus17mlof0.25%bupivacaineand2mlof0.9% normal saline in a total volume of 20 ml on each side

Pain intensity, nausea

There are different methods for random allocation in clinical trial studies, which is one of these methods, and in cases such as when the number in each group is to be selected in equal proportion, this method is appropriate. The size of each block is usually determined as a multiple of 4 or six or eight and so on. The size of all blocks can be considered as a fixed number or it can be considered variable based on the mentioned multiples. After selecting the eligible samples, in this study, randomization will be done by Block Randomization method. became. This process will be done with random allocation software. With the mentioned software, 10 blocks of six will be created. Samples will be assigned to each group based on randomly generated numbers.

Before starting the study, the list of people will be randomly assigned to 2 study groups using a computer. Based on this list, envelopes are prepared, inside which the name of one of the treatment groups is written based on the list of random numbers. These envelopes will be provided to the first expert, and if the patients meet the entry criteria, an envelope will be opened for each patient and their treatment group will be determined based on it. The drug is prepared for injection by the mentioned expert and is handed over to the second expert (who does not know the type of drug) and finally the drug is given to the anesthesia assistant performing TAP Block. The completer of the checklist also has no knowledge of the drug group assigned to each patient.