A comparative study of the effect of tranexamic acid dissolved in hot ,cold and room temperature washing fluid on reducing bleeding during surgery and postoperative complications in TURP surgery

Comparison of the effect of tranexamic acid dissolved in hot, cold and operating room temperature washing fluids on the amount of bleeding during surgery and complications of TURP.

A controlled, parallel-group, single-blind, randomized, phase 2 clinical trial on 80 patients. Randomization was done by block of four method.

Candidates for TURP surgery in Imam Khomeini Hospital of Aeshtar city were randomly divided into four control groups (routine intraoperative washing), intervention 1 (washing with a combination of warm solution and tranexamic acid), intervention 2 (washing with a combination of cold solution and tranexamic acid), intervention 3 (washing They were divided by the combination of room temperature solution and tranexamic acid) and intraoperative washing in each group was determined according to the method. The patients did not know about the washing method in the operating room.

Entry criteria: age over 18 years, prostate weight less than 70 grams, no history of coagulation disorders, no history of cardiovascular diseases, no history of prostate cancer, hemoglobin greater than or equal to 10, no history of atrial fibrillation and coronary artery disease, thrombophilia, severe form Chronic renal failure. Exclusion criteria: the presence of sensitivity to tranexamic acid drug, the need to perform anesthesia other than spinal anesthesia.

Control group: routine intraoperative washing Intervention group 1: intraoperative washing with a combination of warm solution and tranexamic acid Intervention group 2: intraoperative washing with a combination of cold solution and tranexamic acid Intervention group 3: intraoperative washing with a combination of room temperature solution and tranexamic acid

Bleeding Shivering

In the four-Block Random Sampling Method, Different Modes of the four Groups are Written on four Cards and Each is Placed in a Package in an Envelope. These Envelopes are Placed in a Box and the Researcher Does not Know in Which Group the Research units Will be Located until the Card is Selected. Before Confronting the Research units, the Ward Nurse removes One of the Envelopes from the Box without Knowing the Study and the Groups determine which Group the Three Patients who will Enter the Study will be in, Respectively.

The participants were not aware of the washing method in the operating room.

داده های دریافتی از شرکت کنندگان به صورت فردی محرمانه خواهد مانداما نتایج کلی بدون شناسایی فردی منتشر خواهد شد

It can be accessed after completing the research

عموم افراد

In order to reduce problems caused by bleeding in patients undergoing prostate resection surgery, it can be used through the urethra

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