Etomidate and Propofol are common anesthetic agents. Previous studies say that Etomidate can be used in patients with limited hemodynamic reserve and Propofol can lead to more hemodynamic instabilities. This study was done to explore the cardiovascular response during the induction of anesthesia with Etomidate or, for comparison, Propofol in elective orthopedic surgeries. Methods: this study was a double blind randomized clinical trial study including patients 18-45 years of age that were admitted for elective orthopedic surgeries in 2012 and 2013.. Studied population are patients who will hospitalized for having elective orthopedic surgeries on their upper and lower extremities
. Sampling will be done the convenience way and after the first patient is randomly allocated to one of the two groups, the rest of the patients will be alternately and in order of their admission to the hospital allocated to either the group of Propofol induced anesthesia or Etomidate induced anesthesia.
50 patients who has the inclusion criteria wiill be randomly divided into two groups of 25 patients. The
first group undergo general anesthesia by Propofol and the second group is anesthetized by Etomidate
Hemodynamic and cardiovascular indicators such as: SBP , DBP , MAP , HR , O2sat of patients will be measured and recorded before the induction of anesthesia, before intubation, and 1, 3, 5, and 10
minutes afterward
. Finally all the gathered information will be recorded in a computer and wiill be analyzed using SPSS version 20.The Chi-square, T-student and repeated measures ANOVA test were used for data analysis.
Inclusion criteria: being aged from 18 to 45 years old; having no underlying diseases; being of ASA 1 classification; being an applicant for elective orthopedic surgery on upper and lower extremities; not being allergic to anesthetic drugs; not having any expected problems of the airway; receiving no narcotics or sedative drugs before the anesthesia and not being hemodynamic instability before the anesthesia. Patients who were a 4 grade after the induction of anesthesia and laryngoscopy, or their laryngoscopy were lasted longer than 30 seconds, or were not anesthetized using the mentioned dose of drugs and received higher doses, were excluded from the study.