The prophylactic effect of azithromycin and doxycycline in infection caused by hysterosalpingography

Comparison of the effect of oral metronidazole and vaginal probiotics on vaginal microbial flora and investigation of treatment failure in women with bacterial vaginosis.

The present study is a clinical trial without a control group, with parallel groups, double-blind, randomized (using block randomization), phase 3 on 110 patients.

In this double-blind randomization clinical trial, women candidates for hysterosalpingography will be divided into two equal groups of azithromycin and doxydoxycycline by block randomization. In the azithromycin group, patients will receive 1 gram of oral azithromycin as a single dose, and in the doxycycline group, doxycycline 100 mg tablets orally twice a day for 5 days. Finally, the two groups are compared in terms of outcomes.

Conditions for inclusion in the study: 18-55-year-old women who are candidates for hysterosalpingography, referring to the obstetrics and gynecology clinic, infertility clinic, Amir-al Mominin Hospital, Arak; Consent to participate in the study. Conditions for inclusion in the study: History of acute Pelvic inflammatory disease within two months prior to Hysterosalpingography; history of gynecological surgery and other transcervical procedures within two months prior to Hysterosalpingography; The use of multiple antibiotics within two months before hysterosalpingography.

In the azithromycin group, before the hysterosalpingography, the patients in the azithromycin group received a single dose of 1 gram of oral azithromycin, and in the doxycycline group, before the hysterosalpingography, the patients in the doxycycline group received 100 mg of doxycycline twice a day for 5 days

Fever, side effects, uterine and cervical infection, chlamydial infection, need to treat pelvic inflammatory disease, Prophylaxis satisfaction.

The participants will be assigned to two intervention and control groups based on the randomization sequence that will be generated in advance. This sequence is unpredictable and its arrangement is completely random. Block randomization method with 8 blocks will be used to allocate the samples. In this way, using the site www.sealedenvelope.com, blocks of 8 letters A and B are randomly generated based on the sample size. The order of placement of letters A and B in each block from the first block to the last block is considered as a randomization sequence. The production of these blocks and their random sequence is completely done by this site and the researcher does not know how they are sequenced.

For this, one group will receive single-dose azithromycin tablets, and the other group will receive a starch tablet that is similar to azithromycin, and in addition, the doxy group of patients received doxycycline, And in the azithromycin group, they will receive a starch tablet similar to doxycycline with the same duration and dose. Therefore, the women participating in the study are not aware of the type of medicine. In addition, for blinding of the second type, the medicines are given to the patients by the respected observer and each patient will be coded. Not informed.

After conducting this study and analytical studies on it, only a part of the data such as information about the main outcome and patient demographic information will be published to the researchers who do the necessary correspondence with the person in charge of this study.

Access will be from 2023/11/20 to 2026/11/20 for 3 years.

University researchers

Academic researchers or university professors or students who intend to use the data of this study, after obtaining permission from the relevant people mentioned, can use the information of this study in the field of metallurgical studies or other relevant review studies. In addition, if requested, they can use the information of this study for the prerequisites of their future studies and the existence of questions and ambiguities. Using the information of this study is subject to mentioning the names and logos of the responsible persons in this study.

Academic researchers and university professors can make a request to use the data from Dr. Nazila Najdi after contacting the relevant professor by message or email. Dr. Nazila Najdi: Phone: 09183482398 Email: najdinazila@gmail.com Address: Vice Chancellor for Education,Ayatollah Taleghani Hospital, Arak, Iran

Letter writing should be done with professors and universities.