Comparison of ketorolac-induced analgesia with ketamine in lumbar fusion surgery patients using PCA pain pump

Comparison of ketorolac-induced analgesia with ketamine in lumbar fusion patients who use PCA pain pump after surgery

A clinical trial with parallel groups, double-blind, randomized, phase 3 on 20 patients. The online site https://www.sealedenvelope.com/ will be used for randomization.

This study, will be conducted in the Imam Khomeini Teaching-Therapeutic Hospital of Sari in Mazandaran province, 120 patients who are candidates for lumbar fusion surgery who after the operation from PCA pain pumps will participate. The pumps will be marked with numbers 1, 2, and 3, and they will be similar in terms of volume and appearance, which only the project nurse will know about, and other personnel and anesthesiologists will know about it. The three studied groups will not have knowledge.

Candidates for lumbar fusion surgery who use PCA pain pump after the operation. Inclusion criteria: willingness of the patient to participate in the study and obtain informed consent, performed lumbar fusion surgery during the research, aged 20 to 75. Exclusion criteria: history of previous spinal surgery, known sensitivity to ketamine or ketorolac

Ketamine vial: Ketamine used in this study in group A, each milliliter of which contains 50 mg of ketamine (500mg/10ml) and is produced by STEROP-Belgium in Germany.Ketorolac vial: Ketorolac used in this study in group B, each milliliter of which contains 30 mg of ketorolac and is produced by Caspian Tamin Company in Iran.Group C: For group C patients, 20 mg of intravenous morphine, which has reached a volume of 100 cc with normal saline, will be given with a PCA pump.

Pain intensity, the amount of nausea and vomiting

Using the online system https://www.sealedenvelope.com/, patients will be randomly divided into three equal groups of 40 people based on the drugs used as follows: BACACB, CAACBB, CAACBB, CABBAC, .... For group A patients, ketamine and morphin; for group B Ketorolac and morphin and for group C only morphine will be given with a PCA pump.

Before starting the study, the list of people will be randomly assigned to 3 study groups using a computer. Based on this list, envelopes are prepared, inside which the name of one of the treatment groups is written based on the list of random numbers. These envelopes will be provided to the first expert, and if the patients meet the entry criteria, an envelope will be opened for each patient and their treatment group will be determined based on it. The drug is prepared for injection by the mentioned expert and is handed over to the second expert (who does not know the type of drug) and finally the drug is given to the anesthesia assistant performing TAP Block. The completer of the checklist also has no knowledge of the drug group assigned to each patient. The pumps will be marked with numbers 1, 2, and 3 and will be similar in terms of size and appearance, which only the nurse who will be involved in the project will be aware of, and other personnel and anesthesiologists will not be aware of the three studied groups.