The Effect of 8 Weeks of Aerobic endurance Exercise Training with Moderate Intensity on Permeability Inflammatory Indicators of Matrix Metalloproteinases and Specific Tissue Inhibitors of MMPs in Migraine Patients

We hypothesized that moderate aerobic training lowers the serum level of S100B and MDA or increases the serum level of SOD and improves headache indices and general health status in wMIG.

The study is a randomized controlled clinical trial (RCT) with a semi-experimental design (three groups with pre- and post-testing).

Imam reza Hospital, Kermanshah

The inclusion criteria were as follows: (1) no history of regular exercise in the previous 6 months; (2) no chronic diseases such as cardiovascular, hypertension, diabetes, arthritis, cancer, asthma, AIDS, meningitis or MS; (3) confirming headache by the neurologist; (4) Having an age range of 18 to 45 years. Exclusion criteria comprised: (1) situations that researchers understood during the research period, such as pregnancy, breastfeeding and abuse of drugs or alcohol; (2) participation in any additional exercise training programmes; (3) no interest on the part of the volunteer in continuing or making a change in their personal life schedule; (4) contracting COVID-19, and 5) voluntary finished the protocol.

1) exercise+migraineurs group (doing 8 weeks of endurance exercise training, running and taking medicine prescribed by the doctor). 2) non-exercise+migraineurs group (only taking medicine prescribed by the doctor). 3. A healthy control group (without medicine and healthy).

matrix metalloproteinases-2 (MMP-2), matrix metalloproteinases-9 (MMP-9), Inhibitors of matrix metalloproteinases-1(TIMP-1),Inhibitors of matrix metalloproteinases-2 (TIMP-2), S100 calcium-binding protein B(S100B)

First, for the two groups of training and control patients, according to the entry and exit criteria, 30 people were introduced by the attending physician of the Kermanshah migraine patient community. A simple random model was used to divide into two groups, and a random number table tool was used for this model. The random sequence was prepared using Random software. For the healthy group, 15 people were selected as available sampling.

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