Patients who meet the criteria for inclusion in the study were selected by random sampling method and divided into four groups: 1- Zinc oxide with dressing, 2- Vaseline with dressing, 3- Zinc oxide without dressing, 4- Vaseline without dressing and the control group. will be placed. The selection of the ball from the bag will be done by one of the ward nurses who is not aware of the study. Due to the fact that in the present study, an attempt has been made to prevent the occurrence of pressure injuries in all vulnerable points, therefore, the use of zinc oxide and Vaseline will support all pressure points of the body. Since according to studies, the average duration of pressure injury in patients hospitalized in the intensive care unit is the first 10 days, in group 1 and 2 patients, the skin of the patients was examined twice a day for 10 days and using Zing. Oxide will cover all pressure points of the body twice a day in the morning and at night with this medicine. The amount of medicine used varies according to the fitness of the patient, and it is important that all pressure points are well covered with this medicine. In group 1, zinc oxide will be used directly on the skin of patients, and in group 2, gas impregnated with zinc will be used on the skin of patients. Patients in groups 3 and 4, for 10 days and twice a day, the skin of the patients will be examined and all pressure points will be covered with Vaseline. In group 3, Vaseline will be used directly on the skin of patients, and in group 4, gauze impregnated with Vaseline will be used on the skin of patients. The amount of medicine used in this group will also be different according to the size of the patient, and the important thing is that all pressure points are covered with medicine. Treatment centers will be conducted and there will be no intervention in routine nursing care. The skin of the patients was examined by the research team twice within 24 hours and each time when the condition of the patients changed in terms of occurrence of pressure injuries using standard tools and in case of ulcers, the degree, size, location and other cases were recorded in the special file for each patient. The present study will be designed and registered. The members of the research team will carry out the relevant interventions on the patients' beds in order to maintain ethical issues according to the purpose of the research.