Comparison of the effectiveness of three treatment methods, TENS, embedding, acupuncture and drug therapy on the level of interleukin 6 and knee osteoarthritis pain.

Determining the effectiveness of three treatment methods: TENS, embedding acupuncture and drug therapy on the level of interleukin-6 and the pain of patients suffering from knee osteoarthritis.

In this study, 60 patients with mild to moderate osteoarthritis of the knee (based on Kellogg's Scor2-3 and maximum VAS (visual analogue scale) of 5) were selected and after completing the informed consent form, they were numbered and divided into three groups of 20 people with the help of computer sorting software.

All three groups are treated and examined for 8 weeks: Embedding group A is done with cut-gut thread at different points and in a sterile way. Group B is subjected to TENS ligh frequency Group C is treated with 400 mg ibuprofen twice a day at home Each of the patients before the start of the treatment (beginning of the first week) and at the end of the intervention (the end of 8 weeks), 5 cc of venous blood from each patient was taken in three 1.5 cc tubes and transferred to the immunology laboratory while maintaining the cold chain and the level of IL-6 It will be reviewed

Inclusion criteria: 1) Patients diagnosed with knee OA based on ACR 2) Age 50 to 65 years 3) Only one knee is involved 4) Have a VAS pain score of 4 or higher 5) Consent to participate in the study Non-entry criteria: 1) Conflict of 2 knees 1) The surgery has been detailed or is in the process of surgery 2) Knee arthroscopy has been performed in the last year 3) In the last six months, have any therapeutic intervention such as intra-articular injection or acupuncture

group A, TENS group and group C receive ibuprofen.

Changes in the amount of pain; Inflammatory factors; The amount of physical activity; Quality of Life

Using the online site https://www.sealedenvelope.com random allocation of three classes are placed in a.b.c groups. Randomization based on block randomization will be done with blocks of 4 and 6. The prepared blocks will be placed in envelopes. One of the envelopes will be randomly selected according to the order of patients' arrival, and patients will be assigned to groups based on the obtained blocks.