Comparison of postoperative analgesic effect of intravenous acetaminophen versus intravenous caffeine in distal radius surgery

Determining and comparing the analgesia effect of injectable acetaminophen with injectable caffeine in distal radius surgeries

A double-blind clinical trial with a control group, with parallel groups, randomized, phase 3, the number of 30 samples in each group is estimated. Allocation of samples to intervention groups is done using color cards method.

This study is conducted on patients referred to the Shahid Rajaei educational-therapeutic center in Qazvin city, who are candidates for distal radius surgery according to the order of the orthopedic surgeon. Test group A (acetaminophen injection drug 10mg/kg), test group C (caffeine injection drug 1mg/kg) and control group O (normal saline 10 cc) after fully regaining consciousness and expressing pain, it is infused to the patient in 100 cc of normal saline diluted by microset over 30 minutes. The participant and outcome evaluator are blind.

Inclusion criteria: age between 20 and 60 years old; distal radius fracture; general anesthesia. Exclusion criteria: unwillingness to cooperate in the study; heart patients with a history of HTN (heart rate over 100 during surgery/blood pressure over 140 during surgery); occurrence of any problems and complications during the study; pregnancy; breastfeeding and abortion less than 3 months; allergy to acetaminophen/caffeine/morphine; long-term use of corticosteroids, antihistamines, narcotics and painkillers; vision and hearing problems and other disabilities; chronic mental and physical illness; liver patients; history of smoking, alcohol and drugs; the duration of the surgery is less than 45 minutes.

Test group A (acetaminophen injection drug 10mg/kg), test group C (caffeine injection drug 1mg/kg) and control group O (normal saline 10 cc)

The amount and intensity of pain

This study is a double-blind randomized clinical trial that is conducted in patients referred to medical training centers of Qazvin University of Medical Sciences who are candidates for distal radius surgery according to the instructions of the orthopedic surgeon. Patients who met the necessary conditions, after full training by an anesthesiologist and filling in the patient's informed personal consent form, entered the study, after randomly selecting the patients, they were divided into three groups, and then the intervention was carried out.In this way: one of the three test groups will be A (acetaminophen drug), test group C (caffeine drug) and control group O (placebo). Sampling is done using the available method. Allocation of samples to intervention groups will be done using color cards method

This is a double-blind type of experiment, which will be blind for the people participating in the study and evaluating the outcome. In the consent form to participate in the study, it is written for the patient that his presence does not necessarily mean intervention but may be included in the control group.