The effect of ondansetron administration on pain reduction after appendectomy surgery

Determining the effect of ondansetron administration before appendectomy surgery on reducing postoperative pain

A clinical trial with a control group, with parallel design, double-blind, randomized, phase 2 on 80 patients.

Immediately before premedication, 4 mg/cc 2 of ondansetron is used as an injection in normal saline for the case group, and 2 cc of distilled water in normal saline is injected as a placebo for the control group. Premedication is done using intravenous fentanyl 2 micrograms per kilogram of body weight and midazolam 0.03 mg/kg. Blinding is done in such a way that first the ondansetron and placebo drugs are coded by an informed person so that their nature is unknown to the prescriber. Measuring the effect of the drug on the variables is also done by another person who is not aware of the type of drug used in each patient.

The criteria for inclusion were uncomplicated appendectomies, the absence of disorders such as cardiac, respiratory, liver, and neurological diseases, and the absence of drug addiction, and patients with A.S.A, 1 and 2 are included in the study. Exclusion criteria include complicated appendectomies, drug addiction, mental diseases, and blood pressure less than 90/60 or more than 180/110 that requires medical intervention.

Immediately before premedication for the case group, 2 mg/cc of ondansetron is used as an injection in normal saline. Premedication is done using intravenous fentanyl 2 micrograms per kilogram of body weight and midazolam 0.03 mg/kg.

Determining the effect of ondansetron on pain after appendectomy; nausea; vomiting; sedation; shivering

80 patients are randomized blocked in two groups of 40 according to the table provided (attached table) from the Random Allocation software. The way to do it is that first, ondansetron and placebo are coded by a knowledgeable person so that their nature is unknown to the prescriber. Ondansetron and placebo are provided by a knowledgeable person to a person who is unaware of the nature of the codes, and they are prescribed by the same person. It is done by an uninformed person, measuring the effect of the drug on the variables is also done by another person who is not aware of the type of drug used in each patient.

Double-blinding means that neither the study subjects nor the observers (researchers) know who is in which group. The way to do it is to first code the ondansetron drug and the placebo by a knowledgeable person so that their nature for The prescribing person is unknown. Ondansetron and placebo are presented by a person who is aware of the nature of the codes to a person who is unaware of the nature of the codes, and their prescription is done by the same person who is unaware, and the effect of the drug on the variables is measured by another person who knows the type of drug used in each patient. It is not aware.