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Study aim
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Comparison of IVF outcomes in two conventional protocols (antagonist) and Stop GnRH agonist/GnRH antagonist in PCO patients
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Design
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The clinical trial has a control group, with parallel groups, without blinding, randomized, on 60 patients. The random allocation method was a block using WWW.Sealedenvelop.com. The blocks will be 2 alleles of size 6.
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Settings and conduct
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Valiasr Hospital
Patients are entered into two groups with two different ovulation stimulation regimens and oocyte puncture is performed
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Participants/Inclusion and exclusion criteria
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Age 20 to 35 years; PCO criteria based on Rotterdam criteria; Sperm analysis is normal or has the minimum necessary criteria for ICSI; AMH above 5; At least one year of infertility
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Intervention groups
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In the GnRH regimen, Stop starts in the mid-luteal phase (previous cycle) and stops with the onset of menstruation. Then the gonadotropin cycle starts on days 2-3. In both groups, after 5 days, subcutaneous antagonist injection is performed for two days. But in the usual antagonist regimen, gonadotropins start on days 2-3 of the menstrual cycle with a dose of 150-225 units subcutaneously. The patient takes gonadotropin for at least 5 days, and from the 6th day of gonadotropin use, in both vaginal ultrasound groups, folliculography is performed every 2 or 3 days. When the leading follicle reaches the size of 13-14 mm, the antagonist is started. From now on, in both regimes, when at least 2-3 follicles above 18 are observed, the final trigger is done with GnRH agonist, and 34-40 hours later, the puncture is done.
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Main outcome variables
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The number of follicles above 16 mm, the degree of SYNCHRONY of follicles, the number and quality of oocytes, the number and quality of embryos