Investigating the effectiveness of mirtazapine in reducing dependence and the temptation to consume amphetamine and methamphetamine patients referred to addiction treatment clinics

Investigating the effectiveness of mirtazapine in reducing dependence and the temptation to consume amphetamine and methamphetamine patients referred to addiction treatment clinics

A double-blind, placebo-controlled trial to evaluate the effect of mirtazapine compared to placebo. Two groups of 42 people are divided into control and intervention groups. The intervention group is treated with mirtazapine tablets with a dose of 15 mg, and the control group is treated with a placebo with the same shape, smell, taste and usage as mirtazapine. After one week, the drug consumption is doubled in both groups. The drug is taken at night and will last for 12 weeks.

84 patients referred to Ahvaz city are diagnosed by a psychiatric specialist based on DSM V diagnostic criteria. The control group will be treated with a placebo with the same shape, smell, taste and usage as Mirtazapine.

Inclusion criteria: At least one positive urine test for methamphetamine during the hospitalization period Absence of current acute illness that requires long-term medical care Exclusion criteria: Diagnosis of psychotic disorder by SCID-5 Diagnosis of Major Depressive Disorder by SCID-5 Known hypersensitivity or previous adverse reaction to mirtazapine

The intervention group will be treated with mirtazapine tablets at a dose of 15 mg per day. The control group will be treated with a placebo with the same shape, smell, taste and usage as mirtazapine.

Dependence and temptation to consume patients

First, by using the Random number generation plugin in Excel software, a table of random numbers from 1 to 84 is prepared in a non-sequential and scattered manner, and intervention and control is done by assigning numbers to two groups of 42 people. The randomization process is done by the study methodology consultant, and the clinical researchers do not know about the randomization process, and only randomized codes from 1 to 84 will be provided to them.

This study is a double-blind, placebo-controlled trial to evaluate the effect of mirtazapine compared to placebo in reducing the use of amphetamine and methamphetamine. The intervention group will be treated with mirtazapine tablets at a dose of 15 mg per day. The control group will be treated with a placebo with the same shape, smell, taste and usage as mirtazapine. After one week, the drug consumption in both groups was doubled, so that patients in the mirtazapine group took two 15 mg tablets (30 mg in total) and patients in the placebo group took two placebo tablets. The medicine is taken at night and will last for twelve weeks. In this study, both the participants and the evaluator are unaware of the nature of both groups, on this basis, this study will be conducted in a double-blind manner.

There is no problem with publishing

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Group of psychiatrists

The documents and data of this study can be analyzed if it is limited to the population inside Khuzestan province and this research cannot be generalized for other regions. It can be used if you only have documents and references.

Research Vice-Chancellor of Jundishapur University of Medical Sciences, Ahvaz medical School Psychiatry department located in Golestan Blvd, Golestan Hospital, Ahvaz. Postal code 61357-15794 Internet address journal_ajums@yahoo.com 06133113828

He should write a letter to the university security through the vice president of research and finally receive the documents through the vice president himself. This process takes about a week.

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