Comparison of Intranasal Ketamine Spray and Intravenous Morphine in Reducing Headache in Patients with Headache; A Randomized Double-Blinded Clinical Trial

Comparison of Intranasal Ketamine Spray and Intravenous Morphine in Reducing Headache in Patients with Headache

A randomized controlled clinical trial with parallel, double-blind, phase 2 on 100 patients, randomized groups used a random number table.

This double-blind (Researcher and patient) clinical trial was conducted on patients with acute headache referred to emergency departments of Shahid Sadougi and Rahnamon Hospitals in Yazd. Based on random number table, the patients were divided into case groups and control group. Then variables in two groups were measured and recorded; Finally, the data was analyzed using the SPSS software.

The inclusion criteria: older than 14 years and younger than 65 years, pain score greater than or equal to four. The exclude criteria: GCS less than 15, symptoms of increased ICP, symptoms of nerve lateralization, O2 saturation less than 90%, suspected of subarachnoid hemorrhage (SAH), fever and Neck stiffness, history of psychosis, known liver and kidney disease, taking painkillers in the last 4 hours, eye complications, pregnancy and breastfeeding, nasal congestion, drug addiction, systolic blood pressure less than 90 and more than 180, respiratory rate less than 10, pulse rate less than 60 and more than 140, history of allergy to any of the drugs used in the study, brain tumor and not consenting to participate in the project

50 patients who were treated with intranasal ketamine at a dose of 0.7 mg/kg (the maximum dose was considered 40 mg) in the form of three puffs inside each nostril (each puff containing 7 mg of ketamine) and 10 cc of normal intravenous saline were injected slowly.

Severity of pain measured by Visual Analogue Scale

Random number table Based on a random sequence of numbers from Random.org, a table will be prepared, with the first Hundred consecutive numbers in Group A, the next Hundred consecutive numbers in Group B. These numbers will be assigned to each patient in order of referral.

The drug is prepared and prescribed by the triage nurse based on which group the patient is in and none of the patients and the evaluating physician will know the type of prescription drug