Comparing the effect of adding dexmedetomidine and low dose of naloxone to morphine on the pain-free period of post-operative analgesia after spinal anesthesia in cesarean section

Comparison of the effects of morphine along with low dose naloxone and dexmedetomidine during analgesia after cesarean section under spinal anesthesia

Clinical trial with a control group, with parallel groups, doubleblind,randomized, phase 3 on 90 patients. The rand function of Excel software was used for randomization.

This study is a double-blind randomized clinical trial that was conducted in Imam Khomeini Sari Educational-Therapeutic Hospital in Mazandaran province on women who are candidates for elective cesarean delivery between 18 and 50 years old who are the first and second gravid. will be executed. Patients will be randomly divided into three groups A, B and C based on a computerized list which is a statistic and does not know about the people present in the treatment groups. 2) and the receiving patient are not aware of the content of the injected drug.

Entry conditions: women aged 18 to 50 years, elective cesarean delivery, first and second gravidExclusion criteria: patient refusal to participate in the study, failure to create the required level of anesthesia and conversion of spinal anesthesia to general, history of drug addiction, history of sensitivity to any of the drugs used in this research, history of known heart disease vascular, liver, kidney and blood coagulation problems and asthma, scoliosis or kyphosis or morbid obesity, height less than 130 cm and BMI higher than 35

Intervention group: 100 micrograms of morphine with 2.5 cc of bupivacaine 0.5% plus a low dose of 2 micrograms of naloxone. Intervention group: 1 microgram (dexmedetomidine) with 2.5 cc bupivacaine 0.5% Control group: 2.5 cc of bupivacaine 0.5% will be injected intrathecally

Pain intensity, sedation scores

Simple randomization will be divided based on the basic variables: age and gestational age. The participants will be randomly divided into 3 groups: 1) 100 micrograms of morphine with 2.5 cc of bupivacaine 0.5% plus a low dose of 2 micrograms of naloxone 2) 1 microgram of dexmedetomidine with 2.5 cc of bupivacaine 0.5% 3) 2.5cc bupivacaine 0.5% All syringes containing medicine are transparent and in the same volume and different concentrations which are delivered in sealed envelopes, the patients are divided into three groups A, B and C based on the computer list which is a statistic, there is no information about the people present in the treatment groups the people present in the treatment groups

All the syringes containing drugs are transparent and in the same volume and different concentrations, only the project manager (senior anesthesiology assistant) administers morphine, naloxone and dexmedetomidine drugs with a certain effective dose to add to bupivacaine to the second year anesthesiology assistants. to perform spinal) delivers. The injecting doctor (second-year anesthesiology resident) and the receiving patient are not aware of the content of the injected drug.