Comparison of different doses of Intravenous magnesium sulfate on intraoperative anesthetic drugs usage and post operative pain in Posterior Spinal Fusion surgery

Reduce the use of anesthesia,their complications,pain during and after surgery

After obtaining the approval of ethics committee, candidates for posterior spinal fusion surgery who meet the inclusion criteria will be selected and patients will be randomly divided into two groups M (1, 2 , 3) and S (control) that receive equal volume of placebo (normal saline).Five minutes before the onset of anesthesia in group M, a dose of 50 mg/kg of intravenous magnesium sulfate was given in 15 minutes and vanfusion doses of 10,15,20 mg/kg/hr followed up to the end of the operation. The S group was given a dose of bolus with the same volume of normal saline during 15 minutes of vanfusion.

Patients aged 18 to 65 years will be candidates for elective PSF surgery referred to Loghman Hakim Hospital.

Inclusion criteria: Age 18-65 years, no history of drug allergy, no history of thromboembolism, no liver, heart or kidney failure, and coagulation disorders, no anticoagulant drugs, no severe obesity, no neuromascular disease, no calcium channel blockers, physical class of American Society of Anesthesiology I, II (ASA) and patient satisfaction to participate in the study Exclusion criteria: Surgery time greater than 5 hours Changing the Surgical Procedure Bleeding more than 2 liters and requires massive transfusion. Sustained blood pressure drop of more than 25% basal

Patients in group M were given one dose of 50 mg/kg of intravenous magnesium sulfate in 15 minutes and vanfusion doses of 10,15,,20 mg/kg, followed up to the end of the operation. The S group was given a dose of normal saline bolus for 15 minutes.

Blood pressure;Volume of bleeding during surgery;Magnesium Sulfate Dosage; Depth of anesthesia;Pain after the operation

In this clinical trial study, after obtaining the approval of ethics committee, candidates for posterior spinal fusion surgery who meet the inclusion criteria will be selected and patients will be randomly divided into two groups M (1, 2 , 3) and S (control) that receive equal volume of placebo (normal saline). Each patient will be given a sealed envelope containing the information of the study or control group and will be opened by the designated nurse in the operating room. Patients are blind to the study group or placebo. But the anesthesiologist in the operating room will be aware of the type of drug received and the drugs studied by an anesthesiologist will be prepared and prescribed for everyone, patients and other members of the research group will not be aware of the intervention group .Simple random sampling is using random table of numbers.

In this clinical trial study, after obtaining the approval of ethics committee, candidates for posterior spinal fusion surgery who meet the inclusion criteria will be selected and patients will be randomly divided into two groups M (1, 2 , 3) and S (control) that receive equal volume of placebo (normal saline). Each patient will be given a sealed envelope containing the information of the study or control group and will be opened by the designated nurse in the operating room. Patients are blind to the study group or placebo. But the anesthesiologist in the operating room will be aware of the type of drug received and the drugs studied by an anesthesiologist will be prepared and prescribed for everyone, patients and other members of the research group will not be aware of the intervention group

The whole data is potentially shareable after making people unidentifiable.

Start of access period 1 month after publication of results

Researchers working in academic and scientific institutions

For the purpose of academic research

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For the purpose of academic research