Comparison Of Nebulized Ketamine With Intravenous Paracetamol Versus Paracetamol Alone For Post-Operative Analgesia In Paediatric Day Care Anesthesia

Our study aims to study the analgesic efficacy of the nebulized form ketamine with intravenous paracetamol versus paracetamol alone for post-operative analgesia in pediatric cases undergoing general anesthesia for elective tonsillectomy as a day care procedure.

Prospective Study, parallel group, double blind study, non probability consecutive sampling

a double-blind method was used to prevent bias. Participants in group K received intravenous paracetamol 10 mg/kg with nebulized ketamine 2 mg/kg diluted in 5 ml given over 5 minutes 15 minutes before induction whereas group P received intravenous paracetamol 15 mg/kg with nebulization with 5 ml normal saline as placebo 15 minutes before the procedure. The anesthetist preparing the solutions was given sealed non-descript bottles with the nebulizing preparations and the trainee in the operating room did not know of the drug in the nebulizer while also unaware of the study protocol.

Inclusion criteria included all ASA-I and II male and female pediatric patients aged 7-12 years coming to the pre-anesthesia clinic for elective tonsillectomy as a day care procedure. Exclusion criteria included patients with any co-morbidity requiring admission, history of upper or lower respiratory tract infection in the last 2 weeks, major cardiovascular abnormalities, un co-operative patients and patients unwilling to be included in the study.

Patients were divided into two groups K and P with group P to receive intravenous paracetamol 10 mg/kg pre-operatively while group K to receive pre-operative intravenous paracetamol at 10 mg/kg along with nebulized ketamine at 2 mg/kg 15 minutes before induction.

Post-operative median pain scores were calculated in the recovery

Patients were received in the recovery room 1 hour before the procedure and after informed written consent and details of being included in the study, a double-blind method was used to prevent bias. Participants in group K received intravenous paracetamol 10 mg/kg with nebulized ketamine 2 mg/kg diluted in 5 ml given over 5 minutes 15 minutes before induction whereas group P received intravenous paracetamol 15 mg/kg with nebulization with 5 ml normal saline as placebo 15 minutes before the procedure. The anesthetist preparing the solutions was given sealed non-descript bottles with the nebulizing preparations and the trainee in the operating room did not know of the drug in the nebulizer while also unaware of the study protocol.