Comparison of the effects of dexmedetomidine and ketamine on Oddi sphincter tone during ERCP

Comparison of the effects of dexmedetomidine and ketamine on sphincter tone during endoscopic retrograde cholangiopancreatography (ERCP)

Clinical trial with a control group, with parallel groups, double-blind, randomized, phase 2 on 84patients. The rand function of Excel software was used for randomization.

After connecting the monitoring, the patients are hydrated with normal saline serum, and with 0.3 mg/kg of midazolam and 2 micrograms of fentanyl, propofol infusion of 50 to 70 per hour and divided into three groups, the first group of which is ketamine with a dose of 0.5 µg/ kg, the second group will be injected with 0.5 µg/kg of dexmedetomidine and the third group will be injected with Plaspo drug. Oddi's sphincter tone is measured by the doctor performing the ERCP. For patients in both groups, basic vital signs, including mean arterial blood pressure, heart rate, and blood oxygen saturation percentage, are measured and recorded in the information form. After taking the patient's history and his complete examination and recording the results in the file, a vein is taken from the cubital area. Hemodynamic changes (MAP, HR, Sat o2) are measured and compared at 5, 10, 20 and 30 minutes after drug injection.

Entry criteria: ERCP candidate patients who need anesthesia,

The first group is ketamine with a dose of 0.5 µg/kg, the second group is 0.5 µg/kg of dexmedetomidine, and the third group is Plaspo drug.

Oddi sphincter tone and hemodynamic changes

The patients are randomly divided into three groups based on the case number, the patients are placed in separate groups based on the case number, the even and odd number on the right, simple cluster randomization, table of random numbers

In this study, both the patient and the therapist are blinded, including the participants and doctors who do not know which drug they have received

only the data which is associated to result and outcome of study will be published and available for researcher for more research

after the study is published, the data will be available

researchers, academic and scientific institution

in metanalysis and similar study

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