Gabapentin is an anticonvulsant that has been shown to be effective in the treatment of neuropathic and chronic pain. The analgesic effect of its perioperative use has not been fully elucidated. Hysterectomy is one of the most common major gynecologic surgery ,therefore we designed the present study to investigate whether pre-emptive use of gabapentin 600 mg orally could reduce postoperative pain, meperidine consumption and postoperative nausea and vomiting (PONV) in the initial 24-hours after hysterectomy. . A total of 140 patients whom were candidate for elective abdominal hysterectomy randomly assigned to one of two groups according to the method of treatment: gabapentin or placebo in a double-blind manner before hysterectomy. The inclusion criteria were ASA class I and II, nonmalignant status (benign gynecologic disease), general anesthesia, and body mass index (BMI) of 20 to 30 kg/m2. The exclusion criteria were known allergy against gabapentin, epilepsy, motion sickness, chronic pain syndrome, psychiatric disorder and substance abuse, duration of surgery excess 3 hours, and trauma of urinary system or bowel within surgery. Postoperatively, the pain was assessed on a visual analogue scale (VAS) at 1, 4, 8, 12 and 24 hours at rest. Meperidine intramuscularly was used to treat postoperative pain on VAS score and patients demand. Total meperidine and anti emetic drug consumption in the first 24 hours after surgery was also recorded.