Comparing the effectiveness of 5% 5-fluorouracil ointment and 50 microgram calcipotriol ointment in the treatment of genital warts

Comparison of the effectiveness of 5-fluorouracil ointment 5% and calcipotriol ointment 50 micrograms in the treatment of genital warts

A clinical trial without a control group, community-based and practice-oriented, parallel groups, double-blind, randomized, phase 2 on 60 patients (30 people receiving 5-fluorouracil 5% and 30 people receiving calcipotriol 50 micrograms) . A simple randomization method was used for randomization.

To investigate the effectiveness of 5% 5-fluorouracil ointment in genital warts and compare its effect with calcipotriol 50 micrograms, patients diagnosed with genital warts who refer to the skin clinic of Imam Khomeini Hospital, Ahvaz, are randomly divided into two groups. The first group will receive 5% 5-fluorouracil ointment and the second group will receive 50 micrograms of calcipotriol. Then, after 1 month of treatment, the effect of the drug is measured through a clinical examination. Also, the study is conducted in a double-blind manner (patient and interventionist) so that the medicine in the same container will be given to the patients by a non-interventionist.

Inclusion criteria: Patients who are diagnosed with genital warts for the first time or who have not received genital warts treatment in the last three months, and do not have any other skin disease. Exclusion criteria: patients with immune system dysfunction, with a previous history of allergy to the study drugs, and pregnant and lactating women.

Receiving 5% 5-fluorouracil ointment (n=30) and calcipotriol ointment 50 micrograms (n=30) three times a week for one month

The location and size of the lesion, and the number of genital warts

Patients are randomly assigned to two intervention groups using randomized block method. For this purpose, blocks of four are prepared, the name of the intervention is written on two sheets and the name of the comparison is written on the other two sheets. The sheets are piled up and placed in the container, and one sheet is pulled out for each patient without placing it. Then four sheets are returned to the container and this process is repeated until the sample volume is reached.

Patients will be evaluated by another specialist as part of the main research, and the design will be done in a double-blind manner. Medicines are provided to patients in a sealed container which is the same for two groups by a person who does not participate in this study and the patients will not know about its contents due to the similarity of the two types of medicine.

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