Investigating the neuroprotective effect of erythropoietin in patients with severe traumatic brain injury

The role of neuroprotic erythropoietin in overcoming severe brain trauma

Clinical trial with a control group, with parallel groups, double-blind, randomized, phase 3 on 136 patients. It is used for block randomization with sealed envelopes

In Shahid Kamyab Hospital of Mashhad, with a sample size of 136 people who were randomly divided into two groups, and in the experimental group, erythropoietin was injected in the first six hours, and then repeated on the third, sixth, ninth, and twelfth days, subcutaneously, and in the control group, We inject normal saline subcutaneously in the first six hours on the third, sixth, and twelfth days, and the consequences are checked by GCS alertness assessment weekly during hospitalization and six months after discharge with GOS

All patients with severe brain trauma with glasgow scale score (GCS) are less than eight, less than six hours past their trauma and have between 18 and 75 years of age And they have no history of coagulation and DVT disorders and chronic kidney disorders

The sample is divided into two groups after randomization, erythropoietin is injected subcutaneously in one group and normal saline is injected subcutaneously in the other group.

Glasgow coma scale (GCS),Glasgow outcome scale

The envelope method is that the envelopes will be prepared and printed and placed inside the envelope by a member of the research team and random numbers with the help of Randomaize.com. The envelope door will be closed and the contents will not be visible from the outside.The purpose of the study is then first explained to the person who has the conditions set forth, and the person, if desired, signs the informed consent form and removes an envelope and then opens it It enters into the intervention or control group based on the contents of the individual envelope.

The participant and the nurse do not know about the injection drug that is erythropoietin or placebo