Investigating the effect of oral theophylline on complications caused by double J: A Double Blind Clinical Trial

Investigating the effect of oral theophylline on complications caused by double J: A Double Blind Clinical Trial

The study is an interventional study in two control groups (30 people) and intervention (30 people), double-blind (patient and researcher), phase 3, parallel and therapeutic.

This clinical trial will be conducted in Sina Hospital, Urology Research Center, on 60 patients. The first group: Double G treatment along with placebo (30 people). Second group: Double G treatment group along with theophylline (30 people).

Inclusion criteria: Patients undergoing trans ureteral lithotripsy Patients under the endoscopic ureter For other cases that have a bleeding effect, double G is installed for them, Written and informed consent from patients Exclusion criteria: Symptoms of prostatitis/ asthma/ being a smoker Diabetes Gastrointestinal discomfort Insomnia and tremors Taking potassium-sparing diuretics Taking digoxin in patients with heart problems Taking levodopa Taking calcium supplements at the same time/ Taking spironolactone tablets Previous history of hyperkalemia Taking triamterene Taking tablets Amiloride High blood potassium and pregnancy

Treatment group, Double G, along with the use of Teolite with the generic name of Theophylline Retard with a dose of 200 mg, Obidi company, 30 tablets, one daily for one month. Treatment group, double G, and placebo (a capsule containing sugar that looks similar to a probiotic capsule and is prescribed for 4 weeks).

Investigating infection and hematuria caused by double G due to the use and non-use of theophylline along with double G stent placement

The present study is a double-blind, randomized clinical trial. The researcher and the participant will not know about the randomization method. For randomization, the balanced block randomization method is used to generate four blocks. Intervention group A and control group B have been determined. According to the randomization method, we expect the two groups to differ by a maximum of 2 people in terms of the number of people assigned. After the methodologist prepares the randomization sequence using the Sealdenvelop online site, the generated sequence will be available to a technician outside the research team. Quadruple blocks (A or B) are placed in envelopes. After the arrival of the first patient with the inclusion criteria, the envelopes are randomly selected, and the type of patient group is informed to the research team through a trained technician. Based on the randomly selected envelope, the patient is placed in the group (Double G plus placebo: 30 patients) or (Double G plus theophylline: 30 patients).

The present study is a double-blind, randomized clinical trial study. The researcher and the participant will not know how to be placed in the control or intervention groups.The present study is a double-blind, randomized clinical trial study. The researcher and the participant will not know how to be placed in the control group: Double G plus placebo, and the treatment group: Double G plus theophylline.Placebo, a capsule containing sugar resembling a probiotic capsule, is prescribed for 4 weeks.

Demographic information anonymously

One year after publication

En Researchers working in academia, physicians, surgeons and hospitals

En Any analysis can be done with the consent of the main researcher

Sina Hospital, Urology Research Center, Head of Urology Research Center: Dr. Seyed Mohammad Kazem Aghamir 00982166348560

En After reviewing the information by the administrator and epidemiologist, the patient information will be available for the applicant by the provision of a patient's privacy.