Investigating the effect of the combination of hydroalcoholic extracts of Tribulus terrestris, Platanus leaves and Medicago sativa on increasing production of platelets and other blood products in patients with thrombocytopenia: A Randomized Double-Blind Clinical Trial

Determining the effect of the combination of hydroalcoholic extracts of Tribulus terrestris, Platanus leaves and Medicago sativa on increasing production of platelets and other blood products in patients with thrombocytopenia

A clinical trial, with a control group, with a parallel group, double-blind, randomized, line-up phase on 40 patients. A random sequence will be generated using the site: https://www.sealedenvelope.com.

The study population is the patients with thrombocytopenia who refer to the blood and cancer clinic, which is confirmed by a doctor specializing in blood and cancer.

Inclusion criteria: Definitive diagnosis of the patient, age between 18 and 75 years, platelet count test below 150 thousand, no spontaneous bleeding, no pregnancy, completion of the informed consent form, Exclusion criteria: Reduction of platelets below 10,000, with active bleeding, pregnancy

The drug is taken by the patient in the form of 500 mg tablets 3 times a day (1.5 grams per day) for 7 days. The placebo group also receives the placebo with the same volume and 3 times a day.

Platelet؛ White blood cells؛ Red blood cells؛ Hemoglobin؛ Neutrophil؛ Lymphocyte؛ Eosinophil؛ Monocyte

In this study, the block randomization method will be used using blocks of 4. A third person who is not involved in the process of taking patients and evaluating patients will create a random sequence using the site: https://www.sealedenvelope.com and based on the sample size, 10 blocks of 4 will be created. Each patient will be given a unique code that can be created on this site. Therefore, concealment is observed and the people involved in the study do not know in which group the next person will be placed and they will not know about the random sequence and only the statistics consultant will know about the random sequence and the codes will remain with them. The study is double-blind and the drugs are prepared in identical containers, and none of the patients and the person who evaluates the patients will know what drug was received. Medicines are sealed and an arrangement will be adopted that only people of one group will visit on that day during the re-evaluation and this work will be planned by the statistics consultant who knows about the codes.

The study is double-blind and the drugs and placebo are prepared in identical containers, and none of the patients and the person who evaluates the patients will know what drug was received. Medicines are sealed and an arrangement will be adopted that only people of one group will visit on that day during the re-evaluation and this work will be planned by the statistics consultant who knows about the codes.