Comparison the effect of oral oxycodone Vs oral meloxicam on pre-emptive control of postoperative pain after tonsillectomy in adults

Comparison of the effect of oral oxycodone with oral meloxicam on preventive pain control after tonsillectomy surgery in adults.

Clinical trial with parallel groups, triple blind, randomized, phase 2-3 on 70 patients. Random Elocit software will be used for randomization

This study is a randomized, controlled, triple-blind clinical trial, which aims to compare the effect of preventive prescription of two drugs, oxycodone and oral meloxicam, on pain control after tonsillectomy surgery in adults referred to Bou Ali Sina Sari Medical Training Center. 70 candidates for tonsillectomy, including adults with anesthesia class 1 and 2 (ASA), are selected as available. Sampling of all patients over 18 years of age who referred to Bo Ali Sina Hospital in Sari during the fall and winter of 1402, who are candidates for planned tonsillectomy with the indication of hypertrophy of the tonsils, abnormal tonsil size, recurrent tonsillitis or previous tonsillitis.

Inclusion criteria include: candidate for planned tonsillectomy with tonsil hypertrophy indication, abnormal tonsil size, recurrent tonsillitis or previous tonsillitis, history of drug abuse before surgery. And exclusion criteria: history of any allergy to opioids, codeine, acetaminophen, aspirin, NSAID. Any contraindications for the use of NSAIDs (such as stomach ulcers, asthma, angioedema, nasal polyps);

Patients in group O will receive quick-release oxycodone tablets 5 mg (Faran Shimi, Iran) and in group M, meloxicam tablets 15 mg (Razak, Iran) orally 60 minutes before the start of surgery.

The intensity of pain after surgery, the amount of painkillers used, the incidence of pain after surgery

Patients who met the criteria for entering the study were divided into two intervention and control groups using the block randomization method. Random Elokit software will be used to do this. And patients are selected in groups of 4 based on the time they entered the study and assigned to two study groups.

Before the operation, adequate explanations and training will be provided to the patients on how to determine the intensity of the pain after the operation using the NRS (Numeric Rating Scale) standard. Patients in group O will receive quick-release oxycodone tablets 5 mg (Faran Shimi, Iran) and in group M, meloxicam tablets 15 mg (Razak, Iran) orally 60 minutes before the start of surgery. The drug under study has been prepared in a numbered paper package and is given to all patients 60 minutes before the start of anesthesia by the associate nurse of the project, who does not know about the study groups, to be swallowed with a little water. All the prepared packages have two pills, one of which is one of the pills under study and the other pill is a placebo, and in terms of appearance, it completely matches with the other pill under study. The packages were prepared and numbered by the project pharmacologist colleague and The discretion of the prescribing nurse is placed. In our study, both the patient and the prescribing nurse were blinded to the prescribed medication. The surgeon and the pain evaluator based on the NRS criterion also do not know the type of drug used by the patient.