Comparison of the effect of regional analgesia with dexamethasone and dexmedetomidine on spinal surgery

Comparison of the effect of regional analgesia with dexamethasone and dexmedetomidine on spinal surgery

A controlled, parallel-group, double-blind, randomized, phase 3 clinical trial on 120 patients, computer-generated random numbers were used for randomization.

In the operating rooms of Ahvaz Golestan Hospital, after anesthetizing the patient with anesthetics including midazolam, fentanyl, sodium thiopental and atracurium and then intubating the patient, at the rate of 0.1 mg per kilogram of body weight, the patients were divided into 3 main groups and they would be studied.

Inclusion criteria: 16 to 65 year old patients who are candidated for discopathy surgery at ASA I-II level who will undergo 1 or 2 level posterior lumbar spine surgery. Absence of history of allergy to Dexa and Dexm drugs, absence of severe heart and lung disease, arrhythmia, liver and kidney failure or mental illness, absence of history of chronic pain or long-term history of taking painkillers and absence of drug addiction are other criterias that will be included in the study.

Patients are divided into 3 groups. At the end of the operation, for one group, 0.2 mg/kg dexamethasone on gelophene, for the next group, 0.2 mg/kg dexmedetomidine on gelophene and for the third group, normal saline with gelophane is placed in the operation site before suturing the operation site. At the end of the operation, after the extubation of the patient, the postoperative pain will be evaluated every 30 minutes for the first 2 hours and then every 2 hours until 24 hours using a 10 cm VAS.

amount of pain based on VAS scale; duration of analgesia; amount of used sedatives

Entered patients will be randomly divided into three groups with a ratio of 1:1:1 using a table of random numbers generated by the computer. The distribution results will be sealed in a sealed envelope and kept by the research manager. On the day of the procedure, the principal reasercher will hand over the envelope to the anesthesia assistant to prepare the test fluid. In fact, the patients and the anesthesia assistant will be blinded to the type of used adjuvant (Dexmedetomidine or Dexamethasone or placebo).

Entered patients will be randomly divided into three groups with a ratio of 1:1:1 using a table of random numbers generated by the computer. The distribution results will be sealed in a sealed envelope and kept by the research manager. On the day of the procedure, the principal reasercher will hand over the envelope to the anesthesia assistant to prepare the test fluid. In fact, the patients and the anesthesia assistant will be blinded to the type of used adjuvant (Dexmedetomidine or Dexamethasone or placebo).