Comparison of the effect of Apotel and Ketorolac before surgery on pain and the need for narcotics after abdominal surgery during the first 24 hours after surgery.

Determining the effect of Apotel and Ketorolac before surgery on pain and the amount of narcotic consumption after abdominal surgery during the first 24 hours after surgery.

A double-blind randomized clinical trial study, phase 3, with two groups (a group of Apotel 1 gram intravenously and a group of Ketorolac 30 mg intravenously) with a sample size of 64 people in each group Patients are divided into two groups by online random number table.

The location of this clinical trial study is in Bo Ali Hospital, Tehran. The drugs were divided A/B by the head of the surgery department (a group of Apotel 1 g intravenously and a group of Ketorolac 30 mg as a honey injection). Due to the double-blindness of the study, the doctor and the patient will not know which group the patient is in. Medicines were administered to the patients upon entering the operating room and in the recovery room.

Electiveness of action ASA1,2 (American Society of Anesthesiologists) Age 18-65 years Signing a personal consent form to enter the study Non-use of drugs, alcohol, cigarettes and psychotropic drugs Exclusion criteria: Loss of consciousness Hemodynamic disorder Abnormal intraoperative bleeding The length of the operation is more than 4 hours

One hour before the operation, one group received 1 gram of Apotel intravenously and one group received 30 mg of Ketorolac as a honey injection

Pain

In this study, patients were randomly divided into two groups A and B. The randomization method was performed as follows: First, a list of random numbers was generated using Excel software (using the Random Number Generation option). Then, these numbers were randomly assigned to patients. To maintain randomness, random numbers were generated and distributed by an individual independent of the study. In this study, block randomization method was used. In this method, patients were divided into small blocks and then each block was randomly assigned to one of two groups. The following method was used to randomize 128 patients into two groups of 64: First, the patients were divided into 16 blocks of 8 people (each block includes 4 people from group A and 4 people from group B, and each block will have 8 words from A and B). After that, in each block, people enter the groups randomly. Randomization will be done inside each block based on the table of random numbers.

This research is a double-blind clinical trial (in order to make this study double-blind, the drugs used for the patients at the beginning of the study are A/B by the supervisor of the surgery department so that the clinical caregiver and the participants do not know the type of drug received.

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