Evaluating the Effects of vitamin d and vitamin e on the Severity of Premenstrual Syndrome in the affected persons that go to medical-health centers of isfahan university of medical sciences

Object:The objective of the current study is to determine the effect of vitamin D, vitaminE, and the placebo on the severity of PMS in the patients affected by the disease referred to the health centers of Isfahan University of Medical Sciences. Design:The present study study is double blind randomized three groups clinical trial. Setting and conduct: One hundred and fifty of PMS affected women were randomly selected and when the diagnosis was confirmed,assigned to each three group( vitamin D and vitamin E and placebo ).Medical intervention was carried out in two menstrual cycles and the results of pre- and post-test were compared. Participants including major eligibility criteria: being 15-45 years old; having regular menstrual cycle; not being affected by depression or anxiety; not having an acute or chronic disease; not taking medicines or supplements; and not taking regular exercise.The exclusion criteria: pregnancy; willingness to use hormonal contraceptive methods or taking any hormonal treatment; not taking the drug or not filling out the forms regularly; and unwillingness to continue the treatment. Intervention: Daily consumption of Vitamin D( Containing 200 mg of powdered vitamin D of MERK company, prepared by Isfahan Faculty of Pharmacy )or vitamin E(Containing 100 mg of powdered vitamin E of MERK company, prepared by Isfahan Faculty of Pharmacy) or placebo(Containing of Starch, prepared by Isfahan Faculty of Pharmacy) from the first day of the menstrual cycle until the first day of the next menstrual cycle for 2 cycles. main outcome measures variables:The mean score of premenstrual syndrome

Funding for this research was provided by the Research Council of Isfahan University of Medical Sciences