Study the Effect of Intravenous of Dexamethasone versus Magnesium Sulphate on postoperative pain after laparoscopic Cholecystectomy surgery

The effect of intravenous dexamethasone and magnesium sulfate injection on pain after laparoscopic head cystectomy surgery

A double-blind, randomized, phase 3 clinical trial on 60 patients with ASA class I, II, using a simple random assignment method with placement, and after the end of the study, all information was analyzed using the statistical software SPSS for Windows (Version 25, (IBM, corp were investigated.

After referring the patients to the teaching hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences (Golestan and Imam Khomeini), they will be selected and randomly assigned to two groups and after obtaining permission from the Ethics Committee of Ahvaz University of Medical Sciences and completing an informed consent form. Participation in the study, patients will be included in the study based on the criteria.

The study inclusion criteria include patients between 18-70 years old, candidates for elective laparoscopic cholecystectomy surgery, satisfaction with the study exclusion criteria including known allergy to one of the study drugs (dexamethasone/magnesium sulfate), liver-kidney-heart dysfunction, History of taking steroid drugs before surgery, neuromuscular disease, taking opioids or painkillers within 3 days before the study, taking calcium channel blockers, not signing a written consent form.

15 minutes before the start of general anesthesia, patients in group M were given a bolus dose of 50 mg/kg magnesium sulfate for 15 minutes and an infusion of 10 mg/kg magnesium sulfate in normal saline until the end of the procedure, and group D, 1 mg/kg intravenous dexamethasone 15 minutes before induction and 0.4 mg/kg/h will be given as an infusion during the procedure.

Pain

In this study, the samples will be divided into two similar groups of 30 people using a table of random numbers, and in the pre-surgery visit, the necessary examinations will be performed, then 15 minutes before the start of anesthesia, 6 cc/kg of Ringer's normal saline will be administered to the patients. will be given and full monitoring including NIBP/ECG/pulse oximetry will be done, demographic information (age, gender, weight) and vital signs will be recorded in the questionnaire.

60 patients with inclusion criteria will be used in the simple random allocation method with placement. In this way, 60 numbers will be poured into a container, and for each patient, after obtaining informed consent, an envelope will be drawn from the container, and based on the odd or even numbers, they will be divided into two groups: dexamethasone and magnesium sulfate. will be allocated. The even numbers will form the dexamethasone group and the odd numbers will form the magnesium sulfate group, then in order to blind the study, the patient and the researcher and the person who will complete the questionnaires will not know the type of injectable drug and the group under investigation.