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Study aim
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ِDetermination the Effect of Positive End-Expiratory Pressure (PEEP) of 15 CmH2O on the Amount of Bleeding After Emergency Coronary Artery Bypass Surgery (CABG) without Using Cardiopulmonary Bypass Pump.
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Design
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Blocking (blocks of four)
Due to the lack of similar study and the pilot of this research, as well as the number of patients in other studies, the sample size was considered to be 50 patients in each group.
This study has been proposed as a hypothesis by the researchers, and due to the lack of similar studies, it is only predicted that there is a difference in the reduction of bleeding after the operation. Considering the conditions of these patients and the importance of the issue, any reduction in bleeding is important.
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Settings and conduct
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All patients referred to the cardiac emergency of Imam Reza & Qaim hospitals with coronary artery occlusion who candidates for emergency coronary artery bypass surgery.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: All patients who have been diagnosed with coronary artery occlusion and referred to the cardiac emergency department of Imam Reza and Qaim Hospital and after performing the initial diagnostic procedures, are candidates for emergency Coronary artery bypass surgery
Exclusion criteria: Patient's death, lack of consent to participate in the study
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Intervention groups
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In the intervention group, after bypass operation and usual treatment, including FFP injection, tranexamic acid, platelet injection and if necessary, return to the operating room, etc., patients in the ICU were treated with PEEP equivalent to 15 cm H2O until ventilators is needed.
In the conventional treatment group, patients will be treated with PEEP equivalent to 5 cmH2O and other conventional treatments.
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Main outcome variables
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The amount of bleeding from pericardial and thoracic drains (in cc) in the first 6, 12, and 24 hours after surgery