Evaluation the effect of vitamin D3 in improvement clinical parameters of patients with chronic periodontitis-clinical trial

Investigating the effect of vitamin 3D on the average clinical indicators of chronic periodontitis in the group consuming vitamin D3 and the placebo group

A controlled, parallel-group, double-blind, randomized, phase 4 clinical trial on 32 patients. Random allocation software was used for randomization.

This study is a double-blind randomized clinical trial study after the proposal was approved by the Research Council of the Yazd School of Dentistry with a sample size of 32 people in the age group of 30 to 45 years with periodontitis stage 1 and 2 and vitamin D3 deficiency from patients referred to Yazd Faculty of Dentistry is done. The samples will be divided into two experimental and control groups. The experimental group will be given oral vitamin 3D supplement and the control group will be given placebo. After three months, the indicators of bleeding after probing (BOP), pocket depth (PD), clinical adhesion loss (CAL) will be compared in two groups.

Entry criteria: female should be healthy, between 30 and 45 years old, have at least 20 teeth and levels below 30 ng/ml. Inclusion criteria: no recent antibiotic treatment, vitamin D supplements, corticosteroids or immunosuppressive drugs, aspirin use, NSAID use, bisphosphonates or hormone therapy, patients who were in menopause, patients who were pregnant, patient with a history of infective endocarditis, congenital problem or acquired heart defects, immunodeficiency, history of diabetes, calcium deficiency, bone diseases or other systemic conditions that may affect the periodontium and the treatment protocol

Intervention group: the group receiving vitamin d3 soft gel 4000 IU. Control group: the group receiving placebo soft gel without active ingredient.

clinical attachment loss; probing depth; bleeding on probing

Eligible patients are placed in two groups using Random Allocation software version 1.0 under Windows and stratified in a simple random manner based on age so that the two groups are the same in terms of age.

In this study, the study participants and the researcher will be unaware of the division of patients into experimental and control groups, and only a third person outside the study will be aware of the division method. (double-blinding) Vitamin 3D supplement and placebo will be provided to patients in the same containers. (so that the contents of the containers are not visible from the outside)