Evaluation of the effectiveness of curcumin in the prevention of contrast induced nephropathy in following coronary Angiography: A randomized controlled Trial

Evaluation of effectiveness of curcumin in preventing nephropathy caused by contrast in coronary angiography

Double-blind, randomized, placebo-controlled clinical

This study is conducted in the cardiac angiography department of Afshar Hospital in Yazd. 60 non-emergency patients who undergo coronary angioplasty, were randomly selected in two groups of 30 people, treated and They are controlled. Both groups will receive the original treatment needed. The pills of both groups (curcumin and placebo) are similar in appearance, and the research student and the patient are not aware of the drug content. Patients are receive placebo or curcuma tablets twelve hours before surgery.

Age 18 and above .admitted to Afshar Hospital in Yazd who is undergoing coronary angioplasty as a non-emergency. Not receiving nephrotoxic drugs Not taking medicine containing curcumin in the last month There is no history of allergic reaction following the consumption of oral curcumin. Tolerating the use of oral medications Hospitalization in the cardiac intensive care unit for 2 days Informed consent of the patient himself or his legal guardian, Non-entry criteria Pregnant or lactating mothers Allergy to curcumin

Patients are selected in a random permutation case to receive placebo or curcuma tablets twelve hours before surgery. The curcumin tablet used is from Dineh company with the brand name Curcuma, each tablet contains 450 mg of turmeric rhizome powder and 50 mg of turmeric extract. Daru Nama is made by the pharmaceutical laboratory of Shahid Sadoughi Faculty of Pharmacy and it is similar to curcuma drug in terms of shape, size and color.

Prevention of contrast- induced nephropathy in coronary angiography

Patients are divided into groups of 30 people and using statistical software;30 people out of 60 patients are completely randomly placed in the treatment group and 30 people in the placebo group. Randomization unit: individual Randomization tool: statistical software

In this study, the participants, the main researcher, the doctors and the person in charge of data collection are kept blind. In this way, the list of people who are going to take medicine or placebo will be provided to the head of the surgery department with a number.