Evaluation of the pregnancy outcome in the GnRH antagonist protocol with pretreatment in the luteal phase (including oral estradiol with or without GnRH antagonist) in comparison with the microdose GnRH agonist protocol in poor responder patients (Poseidon 3) in patients undergoing fertility treatment at the Milad Infertility Center.(randomized clinical trial)

Comparison of pregnancy rate of GnRH antagonist protocol with oral estradiol pretreatment with or without GnRH antagonist and GnRH flare agonist microdose protocol in Poseidon 3 women

Random assignment to the intervention and control groups in the form of a double-blind random block design with a sample size of 105

This study is conducted at Milad Infertility Center on 105 women under 35 years of age with low ovarian reserves (AMH<1.2 and AFC<5). Participants randomly will be divided into 3 groups using the permutation block method. Sealed envelopes will be used to hide the allocation. The patient-analyst is unaware of the type of treatment.

inclusion criteria : Infertile women candidates for IVF under 35 years of age with regular cycles low ovarian reserves (AMH<1.2 and AFC<5) Exclusion criteria: Male factor of infertility (severe), Having moderate to severe endometriosis Having adenomyosis, Having uterine myoma other than subserous myoma with any moma less than 4 cm BMI>30

In the first group, from the 19th day of the previous cycle, oral estradiol is prescribed at a dose of 4 mg daily for 10 days. Gonadotropins start on the third day of the next period. In the second group, in addition to oral estradiol, cetrorelix subcutaneous ampoule will be added for 3 days from the 26th day of the cycle. Gonadotropins start on the third day of the next period. Control group: First, on the 4th day of the cycle, for 2 weeks, OCP is prescribed, and on the second day of the next menstrual cycle, the GnRH agonist with a dose of 50 micrograms of CinnaFactsubcutaneously, and on the third day of the menstrual cycle, gonadotropins are started.

number of oocytes, M2 oocytes, embryos, chemical pregnancy, clinical pregnancy, and Ongoing pregnancy. Abortion rate

In this study, permutation blocks method was used to generate the sequence of random assignment of people to the studied groups. Random allocation sequence of people was done using Random Allocation Software and random block size. Therefore, the first person is assigned to the control group, the second person to intervention group 2, the third person to the control group, etc. and this process continues until all samples are assigned. The characteristic of this method is that the two study groups will have equal numbers.

Sealed envelopes are used to hide the allocation. Based on the order of arrival of the research units, the envelopes are opened in order and the allocated group is revealed. The patient and the analyst are unaware of the type of treatment.

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