Comparison of two methods of administering magnesium through continuous infusion (۲۴ hours) and short-term infusion (۴ hours) in the correction of hypomagnesemia in patients admitted to the ICU of Sina Hospital: a clinical pilot study

Investigating the hypomagnesemia treatment protocol in patients hospitalized in ICU and comparing the efficacy of two methods of continuous infusion and intermitent infusion.

The randomized clinical trial , non-blind, double-arm and parallel. After confirming hypomagnesemia using the magnesium challenge test, patients will be divided into two groups using the randomization method through permuted blocks of 6 created by the software. This is a pilot study and will be conducted on 30 patients (15 patients in each group).

Patients hospitalized in the ICU of Sinai Hospital, if meet the inclusion criteria, magnesium challenge test is first performed to ensure the identification of hypomagnesemia (If the patient has magnesium deficiency, magnesium retention is more than 50%.). patients divided using the randomization method through blocks of 6; one group received magnesium sulfate for 24hour continuous infusion for 3 days, and other received magnesium sulfate in the form of a 4-hour short infusion for 3 days. washing out in fourth day, then a magnesium challenge test is performed and 24-hour urine is collected. Retention of magnesium is more than 50%, considered no treatment.

patients age over 18 years, who have been hospitalized for less than 96 hours in the ICU and filled out written consent, will be included. If the serum concentration of magnesium is higher than 4 mg/dl, CKD , the 2nd and 3rd degrees heart block, muscle weakness , refractory shockو survival is less than 48 hours, will be excluded

the first group of received magnesium sulfate as a continuous infusion over 24 hours and for 3 days and the second group receive magnesium sulfate as a 4-hour short infusion for 3 days.

Investigating the hypomagnesemia treatment protocol in patients hospitalized in ICU

Using the randomization method, patients are divided into two groups 1:1 ratio, by the randomization table. The permuted block randomization table is generated electronically in block sizes of six. In order to randomize, 5 blocks with 6 column are created, the number of each group in the blocks is equal and randomly, if the patients have the conditions to enter the study, they will be placed in one of the groups in the order of the rows of the block.

Clinical results will be published through an original article and All other data will be available on request

Up to 5 years after publishing the clinical results

Researchers and ethics committee

Ethical evaluation and review articles without financial conflicts of interest.

Responsible Researcher Dr farhadnajmeddin by the following email f-najmeddin@tums.ac.ir

Data will be available within 2 weeks after the email check. The email should include the Conflict of interest disclosure