Investigating The Effect Of Bromelain Gel Added To Periodontal Pack Compared To Periodontal Pack Alone On The Healing Of Palatal Wound Resulting From Harvesting The Free Gingival Graft On Patients With Keratinized Gingival Width Deficiency Who Are Candidates For Gingival Grafting; A Parallel Clinical Trial Study

Evaluation the effect of the bromelain Gel on wound healing after free gingival graft

Two arm parallel group randomized trial with double-blind postoperative care, outcome assessment and participants. Phase 3 on 28 patients. Block method will be used for randomization.

A study on the healing of palatal wound after free gingival grafting will be conducted on patients with keratinized gingival width deficiency who are candidates for gingival grafting in Tehran Faculty of Dentistry with two groups with and without the use of bromelain gel. Participants and analyzers Statistics of the type of surgical technique performed in each patient are blinded.

Inclusion criteria: All patients over 18 years old who need free gingival grafting treatment around teeth or implants, systemically healthy, non-smokers, measuring 10 mm wide and 15 to 20 mm long. Exclusion criteria: presence of periodontal disease, systemic diseases that are contraindications to periodontal surgeries or interfere with tissue repair, pregnancy and breastfeeding.

Control group: for patients in this group, no bromelain gel will be placed on the wound site after surgery, and only the periodontal pack will be placed on the palatal wound area. Intervention group: 1% bromelain gel is placed in the palatal wound area of these patients after surgery, and after applying the gel, a periodontal pack is placed in the palatal wound area.

The average area of the remaining wound in the palate area, the amount of bleeding , the amount of color adaptation, the amount of epithelialization, pain and discomfort, Lundry's healing index

The samples are randomly divided into two groups using balance block randomization (size = 4). For this purpose, the allocation method in each of the blocks is determined using Excel software in such a way that at least 2 samples of any intervention are in each block. The randomization process is carried out by the study methodology consultant. The type of allocation after randomization is noted in the envelope with numbers 1 to 28 for each sample. When conducting the study, the operator opens the envelopes in order and aware of the type of sample's allocation at the time of intervention.

People entered in the study, knowing that they are participating in a research study, are blinded to the allocation to the desired treatment group, and the statistical analyzer is blinded to the type of surgical technique performed in each patient. Both groups receive periodontal packs with the same color, taste and shape, so the patient does not know the presence or absence of gel under the pack.