A comparative study of the sedative and analgesic effects of two combinations of dexmethomidine-ketamine (Ketodex) and propofol-fentanyl (Fenofel) in patients undergoing endoscopic retrograde cholangiopancreatography.

Determine the the sedative effects of and analgesic effects of two combinations of dexmedetomidine-ketamine (Ketodex) to propofol- fentanyl (Fenofol) in patients undergoing Endoscopic Retrograde Cholangiopancreatography

Clinical trial,with parallel groups,three blinded, randomized,phase 3 on 120 patients,random allocation software was used for randomization

This study is a three-blind randomized clinical trial and the community study of patients who are candidates for endoscopic retrograde cholangiopancreatography in the year 2023 are hospitalized.Patients who met all the inclusion criteria after obtaining informed consent,they entered the study.this Patients are randomly divided into 2 groups.

Study inclusion criteria:Age above 18 years,Consent to enter the study,Patients who are candidates for endoscopic retrograde cholangiopancreatography,Patients with American Society of Anesthesiologists (ASA) I,II Criteria for not entering the study:Patients with high blood pressure,coronary heart disease and central nervous system disorders,Patients with known allergies to study drugs,pregnancy,Airway's disease

The Fenofol group received 1 μg/kg fentanyl and 1 mg/kg propofol over 30 seconds,followed by propofol at 2 to 4 mg/kg/h. The Ketodex group received 0/5 μg/kg dexmedetomidine and 1 mg /kg of ketamine as a loading dose infusion over 2 to 5 minutes and received dexmedetomidine at 0.5 μg/kg/h and ketamine at 1 to 2 mg/kg/h

Amount of pain,quality of relaxation,age,sex,oxygen saturation level,diastolic blood pressure,systolic blood pressure,heart rate,duration of ERCP, length of stay in recovery,additional medication for sedation,ASA,underlying disease,disease Background leading to ERCP,duration of anesthesia,patient satisfaction,gastroenterologist satisfaction

Randomization is done in a simple way. The samples are randomly placed in three intervention groups 1, 2 by means of random allocation software. Sampling continues until the samples in all two groups reach the set limit

This study is a triple blind clinical trial, before obtaining the consent to participate in the study from the patients, in addition to explaining to them that they are randomly participating in two drug groups and they will get information about the type of drugs, but in what They will not be informed if they are placed in a group, an anesthesiologist, as the person responsible for collecting data and evaluating the outcome, is not aware of the groups, nor is the statistician, who plays the role of an analyst, aware of the groups, and after receiving the results by the presenter Decoding takes place, so we can do the study in a triple blind way.