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Study aim
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Comparison of the rate of pruritus in intrathecal fentanyl injection in opium-addicted patients in lower limb orthopedic surgeries.
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Design
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Clinical trial with parallel groups, double-blind, randomized
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Settings and conduct
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This study will be conducted on 68 opium-addicted patients who are candidates for elective orthopedic surgeries of the lower limbs under spinal Anesthesia.In the operating room, an anesthesiologist who knows the type of injected substance will enter the subarachnoid space with a 25 and 26 size Quincke spinal needle in a sitting position and at the level of L3-L4 or L4-L5. Then, in the FA groups, 2 ml of 0.5% Marcaine will be injected along with 1 ml of fentanyl, and in the MA group, only 3 ml of Marcaine will be injected.
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Participants/Inclusion and exclusion criteria
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Participants: patients candidates for elective orthopedic surgeries of the lower limbs under spinal anesthesia, entry conditions: people addicted to opium 20-55 years old, anesthesia status in class I and II classification of the American Society of Anesthesiology (ASA), signing an informed consent form, people using Drug addicts who are only addicted to opium. non-entry Conditions for not entering: presence of neurological disorders, presence of coagulation problem, presence of local skin infection at the injection site, presence of high cerebrospinal fluid pressure, presence of sensitivity to local anesthetics, use of corticosteroids in one year. Recent use of antihistamines in the last 8 weeks, history of food and drug allergies, people who use other drugs besides opium.
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Intervention groups
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The first intervention group: a group of addicted people who will receive intrathecal Marcaine together with fentanyl for spinal anesthesia. The second intervention group: a group of addicted people who will receive only intrathecal Marcaine.
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Main outcome variables
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prevalence and intensity itching