Comparison of the effect of Sitagliptin and Inositol on the Oocyte and Embryo Quality in Poly Cystic Ovarian Syndrome (PCOS) Patients Undergoing Intra Cytoplasmic Sperm Injection (ICSI)

Comparison of Mean Levels of Testosterone, Cholesterol, Triglyceride, Oocyte Quality, Embryo Quality, BMI, LH, FSH in Two Groups Treated with Inositol and Sitagliptin Addition to Inositol

The Clinical Trial, One Control Group with a Parallel Group,double Blind, Randomized, Phase 3 on 70 Patients who will be Randomized with Block Method

Body Mass Index and Levels of Fating Blood Sugar, Luteinizing Hormone & Follicle-Stimulation Hormone, Triglyceride, Cholesterol and Testosterone are Evaluated Before Starting in Both Groups. Group A will Receive their Routine Medications Plus Sitagliptin Tablet and Inofolic Powder, and Group B will Receive their Routine Medications Plus Inofolic Powder, 8 Weeks Before the Start of In Vitro Fertilization Cycle in the Infertility Center of Shahid Beheshti Hospital in Kashan, and then Embryo Transfer will be Done with Appropriate Quality. The Quality of Embryo and Oocyte and Laboratory Criteria and Body Mass Index will be Investigated in Two Groups

Inclusion Criteria People with Polycystic Ovarian Syndrome, Age Between 18 and 40 Years Old, Known Case of Polycystic Ovarian Syndrome, and Based on their Infertility Records, are Candidates for Entering the Cycle of Infertility Treatment and ICSI; Exclusion Criteria People with Uterine Abnormalities

Group Treated with Inositol Group Treated with Inositol and Sitagliptin

Embryo Quality, Oocyte Quality

First, the Drug Package of Sitagliptin and Inofolic was Coded with the Letter A and the Drug Package of Inofolic with the Letter B, and then using the Website www.sealdenvelope.com/simple-randomiser/v1/lists, the Randomization List was Selected by Selecting a Sample Size of 70. And it is Prepared by Balanced Quadruple Blocking Method. Then, through the obtained Randomization list, the People Included in the study will be Assigned to one of the two groups A and B. For example, suppose that in the first quartet block, the permutation method is ABBA, so the first and fourth samples will be assigned to group A and the second and third samples will be assigned to group B, and it will continue in this way until the last sample

A person who has no Role in this Trial and is not Aware of the Random Allocation will Allocate the Drugs to thePparticipants, a code will be Placed on the box of the Drugs. The Researcher is Unaware of the Type of Intervention and After Analyzing the Data, the Package Codes will be Decoded. Considering that the Form of Drugs and their Consumption are not the same, one is in the form of Powder and the other is a Tablet, and Considering the Proven Therapeutic Effect of Inofolic Powder in the Treatment of Infertility, Placebo cannot be Considered.