Investigating the effect of preventive dose of dexamethasone on pain, nausea, frequent vomiting and postoperative restlessness in patients undergoing septorhinoplasty.

Determining and comparing the average intensity of pain, nausea, vomiting and restlessness after surgery in patients undergoing septoplasty, rhinoplasty and septorhinoplasty using prompt dose of dexamethasone after induction of anesthesia.

In this triple blind phase3, randomized controlled clinical trial with parallel groups, 70 patients who are candidates for septorhinoplasty are distributed in two groups of 35 by simple random allocation method. In the first group, 0.1 mg/kg of intravenous dexamethasone is injected, and in the control group, the same volume of normal saline is injected.

This triple blind clinical trial study is conducted in Al-Zahra Hospital of Isfahan in 2024. The patients, researcher and data collector are unaware of the type of intervention. Patients randomly allocated to two groups of intervention and control.

Inclusion critera include: candidates for septorhinoplasty, age range 88 to 55 years, agree to participate in the study, ASA class one and two, and elective surgery. The exclusion criteria include: suffering from an underlying disease, history of long-term use of anti-nausea and vomiting drugs and corticosteroids, and history of smoking, suffering from reflux, occurrence of a disorder during the operation that requires medical intervention, changing the operation technique or anesthesia to There are various reasons and the impossibility of collecting data until the end of the study due to reasons such as the death of the patient during the operation.

After induction of anesthesia in the first group, dexamethasone 0.1 mg per kg (about 8 mg) is injected slowly intravenously for each adult. In the control group, normal saline is injected with the same volume and method.

Post operative Pain, Nausea and vomiting, Restlessness after surgery

Randomization of patients is done in a simple way. In this way, the samples are placed in sealed envelopes by number and each patient is asked to choose one envelope from the set of envelopes at the time of visit. Depending on whether the number is odd or even, the patient is assigned to one of the intervention or control groups.

The method of blinding will be such that the patients and the person collecting the data are unaware of the type of drug used. The drugs are prepared by one of the operating room personnel who is not in the course of the study in similar and coded syringes and given to the project manager for injection. Also, the person collecting the data is not aware of the type of drug injected to the patients

The plan belongs to the government organization and it is not possible to share it.