Comparison of the effects of one-stage full-mouth disinfection and quadrant-wise scaling and root planing on serum levels of IL-17 and IL-1β and clinical parameters following treatment of moderate-to-severe chronic periodontitis
Aim:The aim of the present study was to compare the effects of one-stage full-mouth disinfection technique with the quadrant-wise scaling and root planing on serum levels of interleukin 1-beta and interleukin17 in patients with moderate-to-severe chronic periodontitis. Inclusion and exclusion criteria: in patients with moderate-to-severe chronic periodontitis and no systemic disease.
Study population ,sample size and primery outcome :Twenty patients with chronic periodontitis were randomly, and based on inclusion criteria in each group, were selected. In order to evaluate periodontal status, the clinical parameters of bleeding on probing,clinical attachment level ,probing depth ,and modified gingival index were measured and recorded before treatment and at 2- and 4-month intervals after treatment. Immunologic parameters of the study,interleukin 1-beta and interleukin17 serum levels, were determined by special laboratory kits at the same intervals.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT201107267128N1
Registration date:2012-02-18, 1390/11/29
Registration timing:retrospective
Last update:
Update count:0
Registration date
2012-02-18, 1390/11/29
Registrant information
Name
Adileh Shirmohammadi
Name of organization / entity
Tabriz University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 41 1335 5965
Email address
shirmohamadia@tbzmed.ac.ir
Recruitment status
Recruitment complete
Funding source
Tabriz university of medical science
Expected recruitment start date
2010-04-04, 1389/01/15
Expected recruitment end date
2011-04-04, 1390/01/15
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Comparison of the effects of one-stage full-mouth disinfection and quadrant-wise scaling and root planing on serum levels of IL-17 and IL-1β and clinical parameters following treatment of moderate-to-severe chronic periodontitis
Public title
Comparison of the effects of one-stage and quadrant-wise scaling and root planing on serum levels of serologic indices and clinical parameters in patients with periodontal disease
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria : A total of 20 patients, with an age range of 25-70 years, suffering from moderate-to-severe chronic periodontitis were randomly selected. The subjects had at least 12 teeth (irrespective of third molars and teeth with orthodontic appliances, bridgeworks, crowns and implants), with the 30% of the teeth with clinical attachment loss of ≥3 mm and radiographic evidence of bone loss in each group, as specified by the inclusion criteria.
The exclusion criteria included systemic conditions, conditions which delay would healing, a history of radiotherapy or immune-suppressive treatment modalities, pregnancy or breast-feeling, use of systemic antibiotics during the two previous months, a history of continuous consumption of NSATDs and a history of scaling and root planing during the previous year
Age
From 25 years old to 70 years old
Gender
Both
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
40
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee of tabriz university of medical science
Street address
Tabriz university of medical science, Golgasht street, Daneshgah street, Tabriz, Iran
City
Tabriz
Postal code
Approval date
2011-07-12, 1390/04/21
Ethics committee reference number
918
Health conditions studied
1
Description of health condition studied
Chronic periodontitis
ICD-10 code
K05.3
ICD-10 code description
Chronic periodontitis
Primary outcomes
1
Description
Serum levels of IL-17 and IL-1β
Timepoint
Base line,1month,4month
Method of measurement
ELIZA kit
Secondary outcomes
1
Description
Clinical parameters of periodontium
Timepoint
Base line,1 month, 4 month
Method of measurement
Periodontal probing
Intervention groups
1
Description
Intervention:One-stage full-mouth disinfection
Category
Treatment - Other
2
Description
Control:Quadrant-wise scaling and root planing
Category
Treatment - Other
Recruitment centers
1
Recruitment center
Name of recruitment center
Dentistry faculty of tabriz, Periodontics ward
Full name of responsible person
Dr Adileh Shirmohamadi
Street address
Tabriz university of medical science, Golgasht street, Daneshgah street, Tabriz, Iran
City
Tabriz
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Tabriz university of medical science
Full name of responsible person
Naser asl aminabadi
Street address
Dentistry faculty of tabriz-pediatric dentistry ward
City
Tabriz
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Tabriz university of medical science
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Tabriz university of medical science
Full name of responsible person
Amir Reza Babaloo
Position
Periodontist/assistant professor
Other areas of specialty/work
Street address
Tabriz university of medical science, Golgasht street, Daneshgah street, Tabriz, Iran
City
Tabriz
Postal code
Phone
+98 41 1335 5966
Fax
+98 41 1334 6977
Email
amirrezababaloo@yahoo.com
Web page address
http://dentistryfac.tbzmed.ac.ir
Person responsible for scientific inquiries
Contact
Name of organization / entity
Tabriz university of medical science-dentistry faculty
Full name of responsible person
Adileh shirmohammadi
Position
Periodontist/associated professor
Other areas of specialty/work
Street address
Tabriz university of medical science, Golgasht street, Daneshgah street, Tabriz, Iran
City
Tabriz
Postal code
5166614711
Phone
+98 41 1335 5966
Fax
+98 41 1334 6977
Email
shirmohamadia@tbzmed.ac.ir
Web page address
http://dentistryfac.tbzmed.ac.ir
Person responsible for updating data
Contact
Name of organization / entity
Tabriz university of medical science, Dentistry faculty
Full name of responsible person
Adileh shirmohamadi
Position
Periodontist/associated professor
Other areas of specialty/work
Street address
Tabriz university of medical science, Golgasht street, Daneshgah street, Tabriz, Iran
City
Tabriz
Postal code
5166614711
Phone
+98 41 1335 5966
Fax
+98 41 1334 6977
Email
shirmahamadia@tbzmed.ac.ir
Web page address
http://dentistryfac.tbzmed.ac.ir
Sharing plan
Deidentified Individual Participant Data Set (IPD)