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Study aim
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The aim of this study is to measure the serum 25-hydroxyvitamin-D concentration changes of postmenopausal women with chronic periodontitis before and after non-surgical periodontal treatment and to evaluate the correlation between those changes and clinical periodontal parameters.
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Design
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Two arm, parallel, not blinded trial (postoperative care and outcome assessment). Randomization was computerized with concealed randomization sequence carried out at an external site.
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Settings and conduct
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People with inclusion criteria who refer to Tabriz University periodontics ward, enter to study after giving informed consent.
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Participants/Inclusion and exclusion criteria
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inclusion criteria:This study is performed on postmenopausal women who are at least 50 years old, and a year, at least, is passed since the menopause has begun;PD greater than or equal to 5mm; generalized attachment loss greater than or equal to 5 mm(more than 30% of the sites are involved); presence of radiographic evidence of alveolar bone loss.
Exclusion criteria: 1) a history of NSAIDs or antimicrobial drugs intake within a 6 month period before the study;2) history of any periodontal treatment within a 6 month period before the study;3) presence of any systemic disease and infection other than chronic periodontitis;4) presence of aggressive periodontitis;5) presence of systemic diseases that interfere with bone metabolism and immune system, such as kidney failure, diabetes and the presence of bone lesions. 6)use of mouthwashes or vitamin supplements within the previous 3 months
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Intervention groups
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Intervention: Patients in the chronic periodontitis group received nonsurgical periodontal therapy, including oral hygiene instructions(flossing & brushing with Bass technique), and scaling and root planing in one 1hour session.then, 0.12 % chlorhexidine mouthwash(Cosmodent Co.,Gingival KIN,spain) was prescribed for 14 days(15ml for 30seconds twice a day).
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Main outcome variables
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main outcome variables: serum 25-hydroxyvitamin D is a primary variable and clinical periodontal parameters are secondary variables include serum 25-hydroxyvitamin D levels(by venus blood sample) and clinical periodontal parameters(Pocket depth, Clinical attachment loss, Bleeding on probing, Gingival index, Plaque index by periodontal probe) which are recorded at baseline and 3 months later.