Evaluation the effect of intraligamentry injection of the Lornoxicam on the post-operative endodontic pain in tooth with symptomatic irreversible pulpitis (Clinical Trial Study)

Purpose: To determine the effect of intraligamentry injection of Lornoxicam on the intensity of post-operative endodontic pain in the tooth with symptomatic irreversible pulpitis on volunteer patients who are referred to the Endodontic department of Dental University of Islamic Azad University of Tehran in 2011-2012. Design of study: Placebo – Controlled Double Blind Clinical Trial Study. Inclusion criteria: Patients with first or second mandibular molars who need endodontic treatment and with clinical evidence of irreversible Pulpits with moderate to severe pain. Exclusion criteria: Patients with allergy or contraindication toward non-opioid or opioid painkillers such as aspirin or NSAIDs; People who have a history of acute peptic ulcer, during the past 12 months; People who have bleeding problems or have been taking anticoagulant drugs over the past month; Patients who have taken opioid or non opioid or steroid pain killers, antidepressants or sedative drugs. Forty qualified samples (initial estimate which will be come more accurate after the pilot study on 6 patients) will be divided randomly in two groups which both will have an inferior Alveolar injection and before the beginning of the treatment the primary group will receive an injection of 0.4 mL ( 0.2 mL in mesio buccal and 0.2 mL in disto buccal) of Lornoxicam and the control group wil be injected with 0.4 mL of 2% Lidocain with EP 1/180000 (as placebo). Then the patients’ pain will be evaluated with visual Analogue Scale analysis (VAS) 0-9 mm in time intervals of 6, 12, 24 and 48 hours after the treatment.

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