Aim of study: The depression of the immune system function that is typically observed after strenuous exercise is believed to be possibly mediated by stress hormones, cytokines and oxidative stress. The aim of this study was to investigate acute consumption of Coenzyme Q10 supplementation on serum concentrations of Tumor necrosis factor-alpha (TNF-α) during the maximal activity. Methods: Twelve healthy active males (age 21/75 ± 0/64 yr, BMI 23/7±0/94 kg/m2) performed 30-min exercise at 80% to 85% HRmax. Subjects 120 minutes pre-exercise received either of the following regimens: Coenzyme Q10 (2 mg per kg body weight) or placebo (food color). Blood samples were obtained prior to supplement consumption and immediately after exercise, then groups were reversed after 4 days.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT201108287430N1
Registration date:2012-10-31, 1391/08/10
Registration timing:retrospective
Last update:
Update count:0
Registration date
2012-10-31, 1391/08/10
Registrant information
Name
Mohammad Mosaferi Ziaaldini
Name of organization / entity
Shahid beheshti university
Country
Iran (Islamic Republic of)
Phone
+98 51 1881 6344
Email address
mo.mosaferi@mail.sbu.ac.ir
Recruitment status
Recruitment complete
Funding source
This work was financialy supported by Mr. Mohammad Mosaferi Ziaaldini
Expected recruitment start date
2010-07-23, 1389/05/01
Expected recruitment end date
2010-08-06, 1389/05/15
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of Acute Consumption of Coenzyme Q10 Supplementation on TNF-α Serum Levels During Maximal Exercise
Public title
Effect of acute coenzyme Q10 consumption on athletes’ immune system
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion Criteria: Healthy individuals; no history of tobacco and alcohol consumption; no history of Antioxidant drugs and supplements for at least one month before the study; no any of physical activity at least 48 hours before the actual test. Exclusion Criteria: using drugs and antioxidant supplements during the study period; any physical injuries or medical disorders during the study period.
Age
From 19 years old to 27 years old
Gender
Male
Phase
2
Groups that have been masked
No information
Sample size
Target sample size:
15
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Crossover
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Department of Exercise Physiology, School of Physical Education and Sport Sciences, Shahid Beheshti
Street address
Department of Exercise Physiology, School of Physical Education and Sport Sciences, Shahid Beheshti University
City
Tehran
Postal code
19848
Approval date
2009-07-19, 1388/04/28
Ethics committee reference number
D/767/1664
Health conditions studied
1
Description of health condition studied
Immune System
ICD-10 code
D72.9
ICD-10 code description
Disorder of white blood cells, unspecified
Primary outcomes
1
Description
Serum levels of TNF-alpha
Timepoint
before and after Intervention
Method of measurement
TNF-alpha serum levels were measured using ELISA method with comertial kits.
Secondary outcomes
empty
Intervention groups
1
Description
Control subjects consume Dextrose (2 mg per kilogram of body weight)120 minutes before the maximal test..
Category
Placebo
2
Description
study group subjects consume Coenzyme Q10 (2 mg per kilogram of body weight )120 minutes before the maximal test..
Category
Prevention
Recruitment centers
1
Recruitment center
Name of recruitment center
National Olympic and Paralympic Academy of Iran
Full name of responsible person
Mohammad Mosaferi
Street address
City
Tehran
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
This work was financially suported by Mohammad Mosaferi
Full name of responsible person
Mohammad Mosaferi
Street address
Department of Exercise Physiology, School of Physical Education and Sport Sciences, Shahid Beheshti University
City
Tehran
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
This work was financially suported by Mohammad Mosaferi
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Shahid Beheshti unoversity
Full name of responsible person
Mohammad Mosaferi Zaaldini
Position
Master of Science
Other areas of specialty/work
Street address
Department of Exercise Physiology, School of Physical Education and Sport Sciences, Shahid Beheshti University
City
Tehran
Postal code
Phone
+98 21 2243 9970
Fax
Email
amanid@sums.ac.ir
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Davar Amani
Position
Associate Professor
Other areas of specialty/work
Street address
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences
City
Teharn
Postal code
Phone
+98 21 2243 9970
Fax
Email
amanid@sums.ac.ir
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Full name of responsible person
Mohamamd Mosaferi Ziaaldini
Position
Other areas of specialty/work
Street address
City
Postal code
Phone
+98 21 2243 9970
Fax
Email
amanid@sums.ac.ir
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)