The effect of vaginal product based on chamomile for treatment of women with dyspareunia

Objective: This study aims to assess the effect of a vaginal product made from chamomile for treatment of dyspareunia. Design: This study is a single- centered randomized double- blind parallel exploratory trial. 92 women with dyspareunia are divided into two groups: intervention and placebo. Women in intervention group are receiving vaginal product from chamomile and placebo group received the same vaginal product without chamomile. Setting and conduct: Patients who meet inclusion criteria participate in this study. At the beginning of the study FSFI and VAS Questionnaires fill up for patients. After 10 days using treatment, patients are fallowed up for 4 weeks and evaluated with FSFI and VAS questionnaires at the end of study. Inclusion criteria are 18- 49 years sexually active women with dyspareunia at least during the 3 last months; having intercourse at least once during a month; having only one sexual partner; having normal gynecological examination; not using oral contraceptives. Exclusion criteria: use of hormonal drugs, anti-hypertensive and anti-depressant drugs over a month before beginning of the study; pregnancy; breast-feeding; Menopause. Interventions: In intervention group immediately after the end of menstruation, every night before bed for 10 nights, a vaginal tablet of chamomile is placed at the upper end of vagina with applicator. In control group immediately after the end of menstruation, every night before bed for 10 nights, a vaginal tablet of placebo is placed at the upper end of vagina with applicator. Primary outcome is pain during intercourse. Secondary outcomes are lubrication of vagina, arousal, desire, orgasm and satisfaction during intercourse. Allocation of study groups done by random block method.

Tehran University of Medical Sciences