This study will be designe to evaluate the efficacy of administration of Hab-o Shefa during 21 days in the management of acute opioid withdrawal. A total of 90 treatment-seeking opioid dependents will be admitted and randomly assigned to three groups(placebo, Hab-o Shefa and clonidine groups) in a double blind, cotroled trial, using a computer-generated list of random numbers. The study will be conducted from Ceptember of 2011 through December of 2011 on the addiction center Tavalod-e Dobare (the major addiction center affiliated with Welfare Organization, Iran). They will be evaluated prior to admission with ECG and medical history and physical examination and will be assessed after admission with Laboratory tests including CBC, FBS, TG, Chole, AST, ALT, BUN, Crea, Na, K. Common study design for 3 groups included; 1th day each patients receive one purple capsule (cap) and four pink capsules (caps), 2th day receive 2 purple caps and 4 pink caps, 3th - 7th days receive 3 purple and 4 pink caps in four divided doses, 8th – 11th days receive 3 purple and 3 pink caps, 12th – 18th days 3 purple and 2 pink caps, 19th day 2 purple and 1 pink caps, 20th day 1 purple and 1 pink caps. For placebo group all caps contains sugar, for Hab-o Shefa group pink caps; each cap contain 750 mg Hab-o Shefa and purple caps contain sugar, for clonidine group purple caps; each cap contain 0.2 mg clonidine and pink caps contain sugar. Variables that will be checked daily by the investigator and recorded in forms included retention in treatment, rates of successful detoxification, the Subjective Opiate Withdrawal Scale (SOWS) scores, the Objective Opiate Withdrawal Scale (OOWS) scores, Clinical opioid withdrawal Scale (Cows) Scores, intensity of craving, depression Bek, depression Hamilton, drug side effects. The rater, a fourth year resident of Traditional Iranian Medicine (TIM) who will be trained in the use of the scales and will be blind to treatment group. All subjects will be given informed written consent prior to admission. Subjects can withdraw their participation at any time and transfer to a conventional detoxification treatment. The study will be conducted in accordance with the Declaration of Helsinki and was approved by the ethical committee at Shahed University and research steering committee at Shahed University of Medical Sciences.